Growth Factors & Cytokines Recombinant Proteins
Human GHBP Recombinant Protein (RPPB0349)
- SKU:
- RPPB0349
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10912
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human GHBP Recombinant Protein |
| Product Code: | RPPB0349 |
| Size: | 10µg |
| Species: | Human |
| Target: | GHBP |
| Synonyms: | GHR, GHBP, GHIP. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The GHBP solution (1mg/ml) contains 10% Glycerol and Phosphate-Buffered Saline (pH 7.4). |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | FSGSEATAAI LSRAPWSLQS VNPGLKTNSS KEPKFTKCRS PERETFSCHW TDEVHHGTKN LGPIQLFYTR RNTQEWTQEW KECPDYVSAG ENSCYFNSSF TSIWIPYCIK LTSNGGTVDE KCFSVDEIVQ PDPPIALNWT LLNVSLTGIH ADIQVRWEAP RNADIQKGWM VLEYELQYKE VNETKWKMMD PILTTSVPVY SLKVDKEYEV RVRSKQRNSG NYGEFSEVLY VTLPQMSQFTCEEDFYLEHH HHHH |
| Biological Activity: | Measured by ability to inhibit GH-induced proliferation assay using Nb2-11 Rat lymphoma cells in the presence of 1.25ng/ml of human growth hormone. The ED50 for this effect is equal or less than 10ng/ml. |
Growth Hormone Binding Protein or GHR, is a protein, part of the cytokine receptor superfamily. GHR binds to 2 receptors, therefore it enhances signal transduction via dimerization of receptors. In elevated levels, growth hormone operates as an antagonist due to high variance in the binding sites affinities. The antagonist operation can be embellished even more when the binding site is reduced its affinity.
GHBP Human produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 254 amino acids (19-264aa) and having a molecular mass of 29.4kDa.GHBP is fused to a 8 amino acid His tag at C-terminus and purified by proprietary chromatographic techniques.
| UniProt Code: | P10912 |
| NCBI GenInfo Identifier: | 121180 |
| NCBI Gene ID: | 2690 |
| NCBI Accession: | P10912.1 |
| UniProt Secondary Accession: | P10912,Q9HCX2, |
| UniProt Related Accession: | P10912 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Growth hormone receptor |
| NCBI Synonym Full Names: | growth hormone receptor |
| NCBI Official Symbol: | GHR�� |
| NCBI Official Synonym Symbols: | GHBP�� |
| NCBI Protein Information: | growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein |
| UniProt Protein Name: | Growth hormone receptor |
| UniProt Synonym Protein Names: | Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein |
| Protein Family: | Ghrelin |
| UniProt Gene Name: | GHR�� |
| UniProt Entry Name: | GHR_HUMAN |
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