Growth Factors & Cytokines Recombinant Proteins
Human GHBP Recombinant Protein (RPPB0348)
- SKU:
- RPPB0348
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10912
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human GHBP Recombinant Protein |
| Product Code: | RPPB0348 |
| Size: | 10µg |
| Species: | Human |
| Target: | GHBP |
| Synonyms: | Growth Hormone Receptor, Growth Hormone Binding Protein, SomatotropinReceptor GH Receptor, Serum BindingProtein, GHBP, GHIP. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterilefiltered colorless solution. |
| Formulation: | GHBP protein solution (1mg/ml) contains phosphate buffered saline (pH7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greaterthan 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | FSGSEATAAI LSRAPWSLQS VNPGLKTNSS KEPKFTKCRS PERETFSCHWTDEVHHGTKN LGPIQLFYTR RNTQEWTQEW KECPDYVSAG ENSCYFNSSF TSIWIPYCIK LTSNGGTVDEKCFSVDEIVQ PDPPIALNWT LLNVSLTGIH ADIQVRWEAP RNADIQKGWM VLEYELQYKEVNETKWKMMD PILTTSVPVYSLKVDKEYEV RVRSKQRNSG NYGEFSEVLY VTLPQMSQFT CEEDFYLEHH HHHH |
Growth hormone receptor, also known as GHR is part of the cytokinereceptor family.� GHR binds 2 receptormolecules and in this manner induces signal transduction through receptordimerization. Furthermore, at high concentrations, growth hormone performs asan antagonist since there is a large difference in affinities at the respectivebinding sites. The antagonist action can be enhanced further by reducingbinding in the low affinity binding site.
GHBP produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 254 amino acids (19-264a.a.) and having a molecular mass of 29.4kDa (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).GHBP is expressed with an 8 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Code: | P10912 |
| NCBI GenInfo Identifier: | 121180 |
| NCBI Gene ID: | 2690 |
| NCBI Accession: | P10912.1 |
| UniProt Secondary Accession: | P10912,Q9HCX2, |
| UniProt Related Accession: | P10912 |
| Molecular Weight: | 638 |
| NCBI Full Name: | Growth hormone receptor |
| NCBI Synonym Full Names: | growth hormone receptor |
| NCBI Official Symbol: | GHR�� |
| NCBI Official Synonym Symbols: | GHBP�� |
| NCBI Protein Information: | growth hormone receptor; GH receptor; serum binding protein; somatotropin receptor; growth hormone binding protein |
| UniProt Protein Name: | Growth hormone receptor |
| UniProt Synonym Protein Names: | Somatotropin receptorGrowth hormone-binding protein; GH-binding protein; GHBPAlternative name(s):Serum-binding protein |
| Protein Family: | Ghrelin |
| UniProt Gene Name: | GHR�� |
| UniProt Entry Name: | GHR_HUMAN |
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