Enzymes Recombinant Proteins

Human GGCT Recombinant Protein (RPPB1687)

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RPPB1687

Description

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Product Name:Human GGCT Recombinant Protein
Product Code:RPPB1687
Size:20µg
Species:Human
Target:GGCT
Synonyms:Gamma-Glutamylcyclotransferase, CRF21, C7orf24, MGC3077, Cytochrome c-releasing factor 21, GCTG, Ggc, Chromosome 7 open reading frame 24, FLJ11717, EC 2.3.2.4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:The GGCT protein solution (1mg/1ml) is formulated in 20mM Tris-HCl buffer (pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.Please avoid freeze thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSHMANSGCKDVT GPDEESFLYF AYGSNLLTER IHLRNPSAAF FCVARLQDFK LDFGNSQGKT SQTWHGGIAT IFQSPGDEVW GVVWKMNKSN LNSLDEQEGV KSGMYVVIEV KVATQEGKEI TCRSYLMTNY ESAPPSPQYK KIICMGAKEN GLPLEYQEKL KAIEPNDYTG KVSEEIEDII KKGETQTL

GGCT is a member of the family of transferases, specifically the aminoacyltransferases. GGCT protein catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and takes an important part in glutathione homeostasis. GGCT induces release of cytochrome c from mitochondria with resultant induction of apoptosis.

GGCT produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (1-188a.a.) and having a molecular mass of 23.2kDa.GGCT is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GGCT: Catalyzes the formation of 5-oxoproline from gamma- glutamyl dipeptides and may play a significant role in glutathione homeostasis. Induces release of cytochrome c from mitochondria with resultant induction of apoptosis. Belongs to the gamma-glutamylcyclotransferase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 2.3.2.4; Transferase; Apoptosis; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 7p15-p14

Cellular Component: cytosol

Molecular Function:gamma-glutamylcyclotransferase activity; protein homodimerization activity

Biological Process: glutathione biosynthetic process; release of cytochrome c from mitochondria

NCBI Summary:The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
UniProt Code:O75223
NCBI GenInfo Identifier:34222503
NCBI Gene ID:79017
NCBI Accession:O75223.1
UniProt Secondary Accession:O75223,Q9BS37, B2RDN0, B8ZZN4, B8ZZR8,
UniProt Related Accession:O75223
Molecular Weight:19,092 Da
NCBI Full Name:Gamma-glutamylcyclotransferase
NCBI Synonym Full Names:gamma-glutamylcyclotransferase
NCBI Official Symbol:GGCT��
NCBI Official Synonym Symbols:GGC; GCTG; CRF21; C7orf24��
NCBI Protein Information:gamma-glutamylcyclotransferase
UniProt Protein Name:Gamma-glutamylcyclotransferase
UniProt Synonym Protein Names:Cytochrome c-releasing factor 21
Protein Family:Gamma-glutamylcyclotransferase
UniProt Gene Name:GGCT��
UniProt Entry Name:GGCT_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75223
Research Area:
Enzymes
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