Human GFPT1/GFAT Recombinant Protein (RPES3946)

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SKU:
RPES3946
Product Type:
Recombinant Protein
Species:
Human

Description

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Human GFPT1/GFAT Recombinant Protein

Glutamine:fructose-6-phosphate amidotransferase 1 (GFAT), also known as GFPT1, is a N-terminal nucleophile aminotransferase that acts as the rate-limiting enzyme for glucose entry into the hexosamine biosynthesis pathway (HBP) in mammals. GFAT transfers the amino group from the L-glutamine amide to the D-fructose 6-phosphate, producing glutamic acid and glucosamine 6-phosphate. GFAT exists as a homotetramer in cytoplasm, and is proposed to be most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. The entire length of human GFAT contains 1 glutamine amidotransferase type-2 domain that catalyzes the transfer of amide nitrogen from glutamine to the appropriate substrate, and 2 SIS (Sugar Isomerase) domains present in several phosphosugar isomerases and phosphosugar binding proteins. Two isoforms of GFAT have been identified: GFAT1 is predominantly expressed in skeletal muscle, whereas GFAT2 is expressed mainly in the central nervous system. Human GFPT1/GFAT Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.

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