Human GET4 Recombinant Protein (RPPB3588)
- SKU:
- RPPB3588
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q7L5D6
Description
| Product Name: | Human GET4 Recombinant Protein |
| Product Code: | RPPB3588 |
| Size: | 20µg |
| Species: | Human |
| Target: | GET4 |
| Synonyms: | Golgi to ER traffic protein 4 homolog (S. cerevisiae), C7orf20, CEE, CGI-20, TRC35, Golgi to ER traffic protein 4 homolog, Conserved edge-expressed protein, Transmembrane domain recognition complex 35 kDa subunit, GET4. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GET4 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMAAAAAM AEQESARNGG RNRGGVQRVE GKLRASVEKG DYYEAHQMYR TLFFRYMSQS KHTEARELMY SGALLFFSHG QQNSAADLSM LVLESLEKAE VEVADELLEN LAKVFSLMDP NSPERVTFVS RALKWSSGGS GKLGHPRLHQ LLALTLWKEQ NYCESRYHFL HSADGEGCAN MLVEYSTSRG FRSEVDMFVA QAVLQFLCLK NKSSASVVFT TYTQKHPSIE DGPPFVEPLL NFIWFLLLAV DGGKLTVFTV LCEQYQPSLR RDPMYNEYLD RIGQLFFGVP PKQTSSYGGL LGNLLTSLMG SSEQEDGEES PSDGSPIELD |
BAT3 complex is a multiprotein complex which takes part in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. Golgi To ER Traffic Protein 4 (GET4) is a part of the BAT3 complex. The complex functions by helping TA proteins (which contain a single C-terminal transmembrane region) which are captured by ASNA1/TRC40. BAT3 complex synthesizes membrane proteins, interacts with the transmembrane area of recently released TA proteins, and transfers them to ASNA1/TRC40 for targeting.
GET4 Human Recombinant produced in E. coli is. a single polypeptide chain containing 350 amino acids (1-327) and having a molecular mass of 38.9kDa. GET4 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GET4: Component of the BAT3 complex, a multiprotein complex involved in the post-translational delivery of tail-anchored (TA) membrane proteins to the endoplasmic reticulum membrane. TA membrane proteins, also named type II transmembrane proteins, contain a single C-terminal transmembrane region. The complex acts by facilitating TA proteins capture by ASNA1/TRC40: it is recruited to ribosomes synthesizing membrane proteins, interacts with the transmembrane region of newly released TA proteins, and transfers them to ASNA1/TRC40 for targeting. Belongs to the GET4 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Unknown function Chromosomal Location of Human Ortholog: 7p22.3 Cellular Component: cytosol Biological Process: transport |
| UniProt Code: | Q7L5D6 |
| NCBI GenInfo Identifier: | 38570062 |
| NCBI Gene ID: | 51608 |
| NCBI Accession: | NP_057033.2 |
| UniProt Related Accession: | Q7L5D6 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | Golgi to ER traffic protein 4 homolog |
| NCBI Synonym Full Names: | golgi to ER traffic protein 4 |
| NCBI Official Symbol: | GET4�� |
| NCBI Official Synonym Symbols: | CEE; TRC35; CGI-20; C7orf20�� |
| NCBI Protein Information: | Golgi to ER traffic protein 4 homolog |
| UniProt Protein Name: | Golgi to ER traffic protein 4 homolog |
| UniProt Synonym Protein Names: | Conserved edge-expressed protein; Transmembrane domain recognition complex 35 kDa subunit; TRC35 |
| Protein Family: | Golgi to ER traffic protein |
| UniProt Gene Name: | GET4�� |
| UniProt Entry Name: | GET4_HUMAN |
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