Human GEMIN6 Recombinant Protein (RPPB3587)

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RPPB3587

Description

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Product Name:Human GEMIN6 Recombinant Protein
Product Code:RPPB3587
Size:10µg
Species:Human
Target:GEMIN6
Synonyms:Gem-associated protein 6, Gemin-6, SIP2, GEMIN6.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:GEMIN6 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMSEWMKK GPLEWQDYIY KEVRVTASEK NEYKGWVLTT DPVSANIVLV NFLEDGSMSV TGIMGHAVQT VETMNEGDHR VREKLMHLFT SGDCKAYSPE DLEERKNSLK KWLEKNHIPI TEQGDAPRTL CVAGVLTIDP PYGPENCSSS NEIILSRVQD LIEGHLTASQ

Gem-Associated Protein 6 (GEMIN6) is a member of a large macromolecular complex, localized to both the cytoplasm and the nucleus, which takes part in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). SMN, GEMIN2, GEMIN3, GEMIN4, and GEMIN5 are additional members of this complex.

GEMIN6 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 190 amino acids (1-167a.a) and having a molecular mass of 21.9kDa. GEMIN6 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GEMIN6: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus.
UniProt Protein Details:

Protein type:RNA splicing

Chromosomal Location of Human Ortholog: 2p22.1

Cellular Component: cytoplasm; cytosol; nuclear body; nucleoplasm; SMN complex

Molecular Function:protein binding

Biological Process: nuclear import; nuclear mRNA splicing, via spliceosome; spliceosomal snRNP biogenesis

NCBI Summary:GEMIN6 is part of a large macromolecular complex, localized to both the cytoplasm and the nucleus, that plays a role in the cytoplasmic assembly of small nuclear ribonucleoproteins (snRNPs). Other members of this complex include SMN (MIM 600354), GEMIN2 (SIP1; MIM 602595), GEMIN3 (DDX20; MIM 606168), GEMIN4 (MIM 606969), and GEMIN5 (MIM 607005).[supplied by OMIM, Jul 2002]
UniProt Code:Q8WXD5
NCBI GenInfo Identifier:34921901
NCBI Gene ID:79833
NCBI Accession:Q8WXD5.1
UniProt Secondary Accession:Q8WXD5,Q53SI5, Q8WVB4, Q9H5G6, B2RDP8,
UniProt Related Accession:Q8WXD5
Molecular Weight:19kDa
NCBI Full Name:Gem-associated protein 6
NCBI Synonym Full Names:gem nuclear organelle associated protein 6
NCBI Official Symbol:GEMIN6��
NCBI Protein Information:gem-associated protein 6
UniProt Protein Name:Gem-associated protein 6
UniProt Synonym Protein Names:SIP2
Protein Family:Gem-associated protein
UniProt Gene Name:GEMIN6��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8WXD5
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