Description
| Product Name: | Human GDI1 Recombinant Protein |
| Product Code: | RPPB3585 |
| Size: | 10µg |
| Species: | Human |
| Target: | GDI1 |
| Synonyms: | Rab GDP dissociation inhibitor alpha, Rab GDI alpha, GDP Dissociation Inhibitor 1, GDI1, Guanosine diphosphate dissociation inhibitor 1, GDI-1, Oligophrenin-2, XAP-4, GDIL, OPHN2, RABGDIA, XAP4, MRX41, MRX48, 1A, RABGD1A. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | The GDI1 solution (0.25mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMDEEYDV IVLGTGLTEC ILSGIMSVNG KKVLHMDRNP YYGGESSSIT PLEELYKRFQ LLEGPPESMG RGRDWNVDLI PKFLMANGQL VKMLLYTEVT RYLDFKVVEG SFVYKGGKIY KVPSTETEAL ASNLMGMFEK RRFRKFLVFV ANFDENDPKT FEGVDPQTTS MRDVYRKFDL GQDVIDFTGH ALALYRTDDY LDQPCLETVN RIKLYSESLA RYGKSPYLYP LYGLGELPQG FARLSAIYGG TYMLNKPVDD IIMENGKVVG VKSEGEVARC KQLICDPSYI PDRVRKAGQV IRIICILSHP IKNTNDANSC QIIIPQNQVN RKSDIYVCMI SYAHNVAAQG KYIAIASTTV ETTDPEKEVE PALELLEPID QKFVAISDLY EPIDDGCESQ VFCSCSYDAT THFETTCNDI KDIYKRMAGT AFDFENMKRK QNDVFGEAEQ |
GDP Dissociation Inhibitor 1 (GDI1) is expressed mainly in neural and sensory tissues. GDI1 regulates the GDP/GTP exchange reaction of nearly all Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. GDI1 is also promoting the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Mutations in GDI1 have been associated with X-linked nonspecific mental retardation.
GDI1 Human Recombinant produced in E. coli is a single polypeptide chain containing 470 amino acids (1-447) and having a molecular mass of 53 kDa.GDI1 is fused to 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | GDI1: a GDP dissociation inhibitor protein expressed primarily in neural and sensory tissues. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the Rab family, small GTP-binding proteins of the Ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from Rab proteins and release GDP from membrane-bound Rabs. Mutations have been linked to X-linked nonspecific mental retardation. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; G protein regulator, misc. Chromosomal Location of Human Ortholog: Xq28 Cellular Component: Golgi apparatus; neuron projection; protein complex; cytoplasm; midbody; cytosol Molecular Function:protein binding; GDP-dissociation inhibitor activity; Rab GDP-dissociation inhibitor activity; GTPase activator activity; Rab GTPase binding Biological Process: protein transport; regulation of small GTPase mediated signal transduction; small GTPase mediated signal transduction; negative regulation of axonogenesis; signal transduction; Rab protein signal transduction; response to calcium ion; positive regulation of GTPase activity Disease: Mental Retardation, X-linked 41 |
| NCBI Summary: | GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific mental retardation. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31150 |
| NCBI GenInfo Identifier: | 1707886 |
| NCBI Gene ID: | 2664 |
| NCBI Accession: | P31150.2 |
| UniProt Secondary Accession: | P31150,P50394, Q6FG50, Q7Z2G6, Q7Z2G9, Q7Z2H5, Q7Z2I6 |
| UniProt Related Accession: | P31150 |
| Molecular Weight: | 447 |
| NCBI Full Name: | Rab GDP dissociation inhibitor alpha |
| NCBI Synonym Full Names: | GDP dissociation inhibitor 1 |
| NCBI Official Symbol: | GDI1�� |
| NCBI Official Synonym Symbols: | 1A; GDIL; MRX41; MRX48; OPHN2; XAP-4; RABGD1A; RABGDIA�� |
| NCBI Protein Information: | rab GDP dissociation inhibitor alpha; GDI-1; protein XAP-4; rab GDI alpha; oligophrenin-2; mental retardation, X-linked 48; rab GDP-dissociation inhibitor, alpha; guanosine diphosphate dissociation inhibitor 1 |
| UniProt Protein Name: | Rab GDP dissociation inhibitor alpha |
| UniProt Synonym Protein Names: | Guanosine diphosphate dissociation inhibitor 1; GDI-1; Oligophrenin-2; Protein XAP-4 |
| Protein Family: | Guanosine nucleotide diphosphate dissociation inhibitor |
| UniProt Gene Name: | GDI1�� |
| UniProt Entry Name: | GDIA_HUMAN |
