Human GDF5/BMP4 Recombinant Protein (RPES2340)

Human GDF5/BMP4 Recombinant Protein

Growth Differentiation Factor 5(GDF-5, BMP-14) is a member of the BMP family of TGF superfamily proteins. Human GDF-5, -6, and -7 are a defined subgroup of the BMP family. GDF-5 is a dimeric precursor protein that is made up of a 354 amino acid (aa) Nterminal proregion and a 120 amino acid C-terminal mature peptide. Mature human GDF-5 has an amino acid sequence that is very similar to both mature mouse and rat GDF-5, with only 0.1% sequence divergence. GDF-5 signaling is mediated by formation of a heterodimeric complex consisting of a type 1 (BMPR-IB) and a type II (BMPR-IIor Activin RII) serine/threonine kinase receptor which results in the phosphorylation and activation of cytosolic Smad proteins (Smad1, 5, and 8). GDF-5 is involved in a variety of developmental processes, such as limb formation, cartilage development, joint formation, bone morphogenesis, cell survival, and neuritogenesis. GDF-5 expression or its signaling may be affected by GDF-5 inhibition, which can aid the development of osteoarthritis. Human GDF5/BMP4 Recombinant Protein is a highly pure recombinant protein developed by Assay Genie for use in a range of applications.