Cytokines Recombinant Proteins

Human GDF15 Recombinant Protein (RPPB0312)

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SKU:
RPPB0312
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q99988
Research Area:
Cytokines

Description

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Product Name:Human GDF15 Recombinant Protein
Product Code:RPPB0312
Size:10µg
Species:Human
Target:GDF15
Synonyms:GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, NRG-1, GDF15.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I

GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance.

Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids (195-308) and having a molecular mass of 16.7 kDa(molecular weight on SDS-PAGE will appear higher).GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:GDF15: disulfide-linked. Belongs to the TGF-beta family.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular region; extracellular space

Molecular Function:transforming growth factor beta receptor binding

Biological Process: cell development; cell-cell signaling; regulation of apoptosis; regulation of MAPKKK cascade; signal transduction; transforming growth factor beta receptor signaling pathway

NCBI Summary:The protein encoded by this gene belongs to the transforming growth factor-beta (TGF-beta) family. The protein is expressed in a broad range of cell types, acts as a pleiotropic cytokine and is involved in the stress reponse program of cells after cellular injury. Increased protein levels are associated with disease states such as tissue hypoxia, inflammation, acute injury and oxidative stress. [provided by RefSeq, Sep 2015]
UniProt Code:Q99988
NCBI GenInfo Identifier:313104195
NCBI Gene ID:9518
NCBI Accession:Q99988.3
UniProt Secondary Accession:Q99988,O14629, P78360, Q9BWA0, Q9NRT0,
UniProt Related Accession:Q99988
Molecular Weight:
NCBI Full Name:Growth/differentiation factor 15
NCBI Synonym Full Names:growth differentiation factor 15
NCBI Official Symbol:GDF15��
NCBI Official Synonym Symbols:PDF; MIC1; PLAB; MIC-1; NAG-1; PTGFB; GDF-15��
NCBI Protein Information:growth/differentiation factor 15
UniProt Protein Name:Growth/differentiation factor 15
UniProt Synonym Protein Names:Macrophage inhibitory cytokine 1; MIC-1; NSAID-activated gene 1 protein; NAG-1; NSAID-regulated gene 1 protein; NRG-1; Placental TGF-beta; Placental bone morphogenetic protein; Prostate differentiation factor
Protein Family:Growth/differentiation factor
UniProt Gene Name:GDF15��
UniProt Entry Name:GDF15_HUMAN
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