Enzymes Recombinant Proteins

Human GDA Recombinant Protein (RPPB1682)

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SKU:
RPPB1682
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9Y2T3
Research Area:
Enzymes

Description

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Product Name:Human GDA Recombinant Protein
Product Code:RPPB1682
Size:5µg
Species:Human
Target:GDA
Synonyms:Guanine Deaminase, Guanine Aminohydrolase, GuanineAminase, P51-Nedasin, EC 3.5.4.3, GUANASE, GAH, Cytoplasmic PSD95 Interactor,KIAA1258, NEDASIN, CYPIN.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:GDA protein solution (1mg/ml) containing PhosphateBuffered Saline (pH 7.4), 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrierprotein (0.1% HSA or BSA).�Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:MCAAQMPPLA HIFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEEASQQEKLAKEWCF KPCEIRELSH HEFFMPGLVD THIHASQYSF AGSSIDLPLL EWLTKYTFPA EHRFQNIDFAEEVYTRVVRR TLKNGTTTAC YFATIHTDSS LLLADITDKF GQRAFVGKVC MDLNDTFPEY KETTEESIKETERFVSEMLQ KNYSRVKPIV TPRFSLSCSE TLMGELGNIA KTRDLHIQSH ISENRDEVEA VKNLYPSYKNYTSVYDKNNL LTNKTVMAHG CYLSAEELNV FHERGASIAH CPNSNLSLSS GFLNVLEVLK HEVKIGLGTDVAGGYSYSML DAIRRAVMVS NILLINKVNE KSLTLKEVFR LATLGGSQAL GLDGEIGNFE VGKEFDAILINPKASDSPID LFYGDFFGDI SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF SSSV

GDA is a member of the ATZ/TRZ family and is in charge for the hydrolytic deamination of guanine. GDA takes part in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for GDA.

GDA Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 454amino acids (1-454 a.a) andhaving a molecular mass of 51kDa.GDA is purified by proprietary chromatographictechniques.

UniProt Protein Function:GDA: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. Belongs to the ATZ/TRZ family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Nucleotide Metabolism - purine; EC 3.5.4.3; Hydrolase

Chromosomal Location of Human Ortholog: 9q21.13

Cellular Component: intracellular; cytosol

Molecular Function:guanine deaminase activity; zinc ion binding

Biological Process: nervous system development; nucleobase, nucleoside and nucleotide metabolic process; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process; purine nucleotide catabolic process; guanine catabolic process; purine base metabolic process

NCBI Summary:This gene encodes an enzyme responsible for the hydrolytic deamination of guanine. Studies in rat ortholog suggest this gene plays a role in microtubule assembly. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
UniProt Code:Q9Y2T3
NCBI GenInfo Identifier:9910736
NCBI Gene ID:9615
NCBI Accession:Q9Y2T3.1
UniProt Secondary Accession:Q9Y2T3,Q5SZC7, Q9H335, Q9ULG2, B4DTY5,
UniProt Related Accession:Q9Y2T3
Molecular Weight:454
NCBI Full Name:Guanine deaminase
NCBI Synonym Full Names:guanine deaminase
NCBI Official Symbol:GDA��
NCBI Official Synonym Symbols:CYPIN; GUANASE; NEDASIN��
NCBI Protein Information:guanine deaminase; GAH; p51-nedasin; guanine aminase; guanine aminohydrolase; cytoplasmic PSD95 interactor
UniProt Protein Name:Guanine deaminase
UniProt Synonym Protein Names:Guanine aminohydrolase; GAH; p51-nedasin
UniProt Gene Name:GDA��
UniProt Entry Name:GUAD_HUMAN
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