Human GCSAM Recombinant Protein (RPPB3583)

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SKU:
RPPB3583
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8N6F7

Description

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Product Name:Human GCSAM Recombinant Protein
Product Code:RPPB3583
Size:20µg
Species:Human
Target:GCSAM
Synonyms:GCAT2, HGAL, Germinal center-associated signaling and motility protein, Germinal center B-cell-expressed transcript 2 protein, Germinal center-associated lymphoma protein, GAL, GCET2 .
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GCSAM solution (0.5mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl, 50% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGNSLLR ENRRQQNTQE MPWNVRMQSP KQRTSRCWDH HIAEGCFCLP WKKILIFEKR QDSQNENERM SSTPIQDNVD QTYSEELCYT LINHRVLCTR PSGNSAEEYY ENVPCKAERP RESLGGTETE YSLLHMPSTD PRHARSPEDE YELLMPHRIS SHFLQQPRPL MAPSETQFSH L

GCSAM is a protein which functions in signal transduction pathways and whose expression raises in germinal cell lymphomas. GCSAM contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, GCSAM expression is particularly induced by interleukin-4.

GCSAM Human Recombinant produced in E. coli is a single polypeptide chain containing 201 amino acids (1-178) and having a molecular mass of 23 kDa. GCSAM is fused to 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GCET2: a protein expressed in normal germinal center B cells, immature B and T cells. Induced by IL4. Its expression strongly predicts survival in diffuse large B-cell lymphoma. Protein type: Unknown functionChromosomal Location of Human Ortholog: 3q13.2Molecular Function: actin binding; myosin II binding; protein binding; protein kinase bindingBiological Process: regulation of B cell receptor signaling pathway
UniProt Protein Details:
NCBI Summary:This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:Q8N6F7
NCBI GenInfo Identifier:74729123
NCBI Gene ID:257144
NCBI Accession:Q8N6F7.1
UniProt Secondary Accession:Q8N6F7,C9JD17, C9JUG6
UniProt Related Accession:Q8N6F7
Molecular Weight:19,206 Da
NCBI Full Name:Germinal center-associated signaling and motility protein
NCBI Synonym Full Names:germinal center associated signaling and motility
NCBI Official Symbol:GCSAM��
NCBI Official Synonym Symbols:HGAL; GCAT2; GCET2��
NCBI Protein Information:germinal center-associated signaling and motility protein
UniProt Protein Name:Germinal center-associated signaling and motility protein
UniProt Synonym Protein Names:Germinal center B-cell-expressed transcript 2 protein; Germinal center-associated lymphoma protein; hGAL
Protein Family:
UniProt Gene Name:GCSAM��
UniProt Entry Name:
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