Human GCHFR Recombinant Protein (RPPB3582)

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SKU:
RPPB3582
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P30047

Description

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Product Name:Human GCHFR Recombinant Protein
Product Code:RPPB3582
Size:20µg
Species:Human
Target:GCHFR
Synonyms:GFRP, HsT16933, P35,GTP cyclohydrolase 1 feedback regulatory protein, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:GCHFR protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 40% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMPYLLIS TQIRMEVGPT MVGDEQSDPE LMQHLGASKR RALGNNFYEY YVDDPPRIVL DKLERRGFRV LSMTGVGQTL VWCLHKE

GTP Cyclohydrolase I Feedback Regulator, also known as GCHFR, is a Protein coding gene which includes a homodimer. GCHFR binds and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. GCHFR also regulates phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide.

GCHFR Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 107 amino acids (1-84a.a) and having a molecular mass of 12.1kDa. GCHFR is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:GCHFR: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. Belongs to the GFRP family.Protein type: InhibitorChromosomal Location of Human Ortholog: 15q15Cellular Component: cytoplasm; cytosol; dendrite; melanosome; nuclear membrane; nucleusMolecular Function: protein bindingBiological Process: neurotransmitter metabolic process; nitric oxide biosynthetic process; regulation of nitric-oxide synthase activity
UniProt Protein Details:
NCBI Summary:GTP cyclohydrolase I feedback regulatory protein binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. [provided by RefSeq, Jul 2008]
UniProt Code:P30047
NCBI GenInfo Identifier:2506906
NCBI Gene ID:2644
NCBI Accession:P30047.3
UniProt Secondary Accession:P30047,Q2M1Q2, Q99749, B2R4L6, B7ZLM8
UniProt Related Accession:P30047
Molecular Weight:8,555 Da
NCBI Full Name:GTP cyclohydrolase 1 feedback regulatory protein
NCBI Synonym Full Names:GTP cyclohydrolase I feedback regulator
NCBI Official Symbol:GCHFR��
NCBI Official Synonym Symbols:P35; GFRP; HsT16933��
NCBI Protein Information:GTP cyclohydrolase 1 feedback regulatory protein
UniProt Protein Name:GTP cyclohydrolase 1 feedback regulatory protein
UniProt Synonym Protein Names:GTP cyclohydrolase I feedback regulatory protein; p35
Protein Family:GTP cyclohydrolase 1 feedback regulatory protein
UniProt Gene Name:GCHFR��
UniProt Entry Name:GFRP_HUMAN
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