Human GBA3/CBGL1 Recombinant Protein (RPES0853)
- SKU:
- RPES0853
- Product Type:
- Recombinant Protein
- Species:
- Human
Description
Human GBA3/CBGL1 Recombinant Protein
Cytosolic beta-glucosidase, also known as Cytosolic beta-glucosidase-like protein 1, GBA3, CBG and CBGL1 is a cytoplasm protein which belongs to the glycosyl hydrolase 1 family and Klotho subfamily. GBA3 / CBGL1 is a glycosidase probably involved in the intestinal absorption and metabolism of dietary flavonoid glycosides. GBA3 / CBGL1 is present in small intestine (at protein level). GBA3 / CBGL1 is expressed in liver, small intestine, colon, spleen and kidney. GBA3 / CBGL1 is down-regulated in renal cell carcinomas and hepatocellular carcinomas. GBA3 / CBGL1 is able to hydrolyze a broad variety of glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens. GBA3 / CBGL1 possesses beta-glycosylceramidase activity and may be involved in a nonlysosomal catabolic pathway of glycosylceramide.
| Product Name: | Human GBA3/CBGL1 Recombinant Protein (RPES0853) |
| Product Code: | RPES0853 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Baculovirus-Insect Cells |
| Synonyms: | CBG,CBGL1,GBA3,GLUC,KLrP,MGC104276,MGC126878 |
| Accession: | NP_066024.1 |
| Sequence: | Met 1-Leu 469 |
| Fusion tag: | C-His |
| Activity: | Measured by its ability to hydrolyze 4-methylumbelliferyl-?-D glucopyranoside. The specific activity is >1,500 pmoles/min/µg. |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | A DNA sequence encoding the human GBA3 (NP_066024.1) (Met 1-Leu 469) was fused with a polyhistidine tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 55 kDa |
| AP Mol Mass: | 50 kDa |
| Formulation: | Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 7.4 |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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