Human GAS7 Recombinant Protein (RPPB3580)

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SKU:
RPPB3580
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60861

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human GAS7 Recombinant Protein
Product Code:RPPB3580
Size:50µg
Species:Human
Target:GAS7
Synonyms:GAS7, GAS-7, Growth arrest-specific protein 7, KIAA0394, MGC1348, MLL/GAS7.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The GAS7 protein solution contains 20mM Tris-HCl, pH-8, 100mM NaCl, 2mM DTT and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MKPGMVPPPP GEESQTVILP PGWQSYLSPQ GRRYYVNTTT NETTWERPSS SPGIPASPGS HRSSLPPTVN GYHASGTPAH PPETAHMSVR KSTGDSQNLG SSSPSKKQSK ENTITINCVT FPHPDTMPEQ QLLKPTEWSY CDYFWADKKD PQGNGTVAGF ELLLQKQLKG KQMQKEMSEF IRERIKIEED YAKNLAKLSQ NSLASQEEGS LGEAWAQVKK SLADEAEVHL KFSAKLHSEV EKPLMNFREN FKKDMKKCDH HIADLRKQLA SRYASVEKAR KALTERQRDL EMKTQQLEIK LSNKTEEDIK KARRKSTQAG DDLMRCVDLY NQAQSKWFEE MVTTTLELER LEVERVEMIR QHLCQYTQLR HETDMFNQST VEPVDQLLRK VDPAKDRELW VREHKTGNIR PVDMEI

GAS7 is mainly expressed in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 is involved in neuronal development by promoting maturation and morphological differentiation of cerebellar neurons. Inhibition of GAS7 production in terminally differentiating cultures of embryonic murine cerebellum impedes neurite outgrowth. Over-expression of GAS7 initiats the development of human osteosarcoma.

GAS7 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 436 amino acids (1-416a.a.) and having a molecular mass of 49.8 kDa.GAS7 is fused to 20 amino acid His Tag at N-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:GAS7: May play a role in promoting maturation and morphological differentiation of cerebellar neurons. A chromosomal aberration involving GAS7 is found in acute myeloid leukemia. Translocation t(11;17)(q23;p13) with MLL/HRX. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Cell development/differentiation; Actin-binding; Transcription factor; Oncoprotein

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: ruffle; cytoplasm; actin filament

Molecular Function:actin filament binding; transcription factor activity

Biological Process: regulation of cell shape; actin filament bundle formation; regulation of transcription, DNA-dependent; actin filament polymerization; cell cycle arrest; neurite morphogenesis

NCBI Summary:Growth arrest-specific 7 is expressed primarily in terminally differentiated brain cells and predominantly in mature cerebellar Purkinje neurons. GAS7 plays a putative role in neuronal development. Several transcript variants encoding proteins which vary in the N-terminus have been described. [provided by RefSeq, Jul 2008]
UniProt Code:O60861
NCBI GenInfo Identifier:218512092
NCBI Gene ID:8522
NCBI Accession:O60861.3
UniProt Related Accession:O60861
Molecular Weight:Observed: 50 kDaPredicted: 55 kDa
NCBI Full Name:Growth arrest-specific protein 7
NCBI Synonym Full Names:growth arrest specific 7
NCBI Official Symbol:GAS7��
NCBI Protein Information:growth arrest-specific protein 7
UniProt Protein Name:Growth arrest-specific protein 7
Protein Family:Growth arrest-specific protein
UniProt Gene Name:GAS7��
UniProt Entry Name:GAS7_HUMAN
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Developmental Biology Recombinant Proteins

system_update_altDatasheetHuman GAS7 Recombinant Protein Growth Arrest-Specific Protein 7 (GAS7) is expressed primarily in terminalaly differentiated brain cells and predominantly in mature cereb