Human GADD45G Recombinant Protein (RPPB3572)

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SKU:
RPPB3572
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O95257

Description

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Product Name:Human GADD45G Recombinant Protein
Product Code:RPPB3572
Size:50µg
Species:Human
Target:GADD45G
Synonyms:DDIT2, GADD45gamma, GADD45G, Growth arrest and DNA-damage-inducible protein GADD45 gamma, Cytokine-responsive protein CR6, DNA-damage-inducible transcript 2, DDIT-2, CR6, GRP17.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GADD45G protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MTLEEVRGQD TVPESTARMQ GAGKALHELL LSAQRQGCLT AGVYESAKVL NVDPDNVTFC VLAAGEEDEG DIALQIHFTL IQAFCCENDIDIVRVGDVQR LAAIVGAGEE AGAPGDLHCI LISNPNEDAW KDPALEKLSL FCEESRSVND WVPSITLPE

GADD45G is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45G reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45G acts as a new-age tumor suppressor however is being frequently inactivated epigenetically in multiple tumors. GADD45G mRNA expression is down-regulated in hepatocellular carcinoma. GADD45G causes cell cycle arrest at G2/M transition when transfected into Hep-G2 cells. GADD45 Gamma induction by androgens involves new protein synthesis. Overexpression of GADD45 Gamma inhibits cell growth and causes morphological modifications in prostate cell lines thus GADD45 gamma takes part in differentiation induction by androgens.

GADD45G Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 159 amino acids and having a molecular mass of 17.1 kDa.

UniProt Protein Function:GADD45G: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.
UniProt Protein Details:

Protein type:Apoptosis; DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 9q22.2

Cellular Component: cytoplasm; nucleus

Molecular Function:protein binding

Biological Process: activation of MAPKKK activity; positive regulation of apoptosis; positive regulation of JNK cascade; regulation of cell cycle

NCBI Summary:This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The GADD45G is highly expressed in placenta. [provided by RefSeq, Jul 2008]
UniProt Code:O95257
NCBI GenInfo Identifier:6919892
NCBI Gene ID:10912
NCBI Accession:O95257.1
UniProt Secondary Accession:O95257,Q5VZ87, Q9C076,
UniProt Related Accession:O95257
Molecular Weight:17kDa
NCBI Full Name:Growth arrest and DNA damage-inducible protein GADD45 gamma
NCBI Synonym Full Names:growth arrest and DNA damage inducible gamma
NCBI Official Symbol:GADD45G��
NCBI Official Synonym Symbols:CR6; DDIT2; GRP17; GADD45gamma��
NCBI Protein Information:growth arrest and DNA damage-inducible protein GADD45 gamma
UniProt Protein Name:Growth arrest and DNA damage-inducible protein GADD45 gamma
UniProt Synonym Protein Names:Cytokine-responsive protein CR6; DNA damage-inducible transcript 2 protein; DDIT-2
Protein Family:Growth arrest and DNA damage-inducible protein
UniProt Gene Name:GADD45G��
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