Human GADD45B Recombinant Protein (RPPB3571)

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SKU:
RPPB3571
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O75293

Description

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Product Name:Human GADD45B Recombinant Protein
Product Code:RPPB3571
Size:50µg
Species:Human
Target:GADD45B
Synonyms:MYD118, GADD45BETA, GADD45B, Growth arrest and DNA-damage-inducible protein GADD45 beta, Myeloid differentiation primary response protein MyD118, Negative growth regulatory protein MyD118, DKFZp566B133.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The GADD45B protein solution contains 20mM Tris-HCl pH-7.5 and 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIVRVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER

GADD45B is part of the nuclear proteins to interact with various proteins whose transcript levels are raised after stressful growth arrest conditions and treatment with DNA-damaging agents. GADD45B reacts to environmental stresses by mediating activation of the p38/JNK pathway which is mediated through their protein binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. GADD45B is involved in the regulation of growth and apoptosis. GADD45b takes part during chondrocyte terminal differentiation and mediates MMP-13 gene expression. GADD45 in B cells is induced by CD40 via a mechanism that involves NF-kappa B and that induction suppresses Fas-mediated killing. GADD45b is down-regulated in most cases of hepatocellular carcinoma (HCC), and is a molecular marker in the diagnosis of HCC and as a possible therapeutic target.

GADD45B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 160 amino acids and having a molecular mass of 17.8 kDa.

UniProt Protein Function:GADD45B: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. Belongs to the GADD45 family.Protein type: Cell development/differentiation; ApoptosisChromosomal Location of Human Ortholog: 19p13.3Cellular Component: cytoplasm; nucleusMolecular Function: protein bindingBiological Process: activation of MAPKK activity; apoptosis; positive regulation of apoptosis; regulation of cell cycle; multicellular organismal development; activation of MAPKKK activity; positive regulation of JNK cascade; negative regulation of protein kinase activity; response to stress; cell differentiation
UniProt Protein Details:
NCBI Summary:This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
UniProt Code:O75293
NCBI GenInfo Identifier:86991436
NCBI Gene ID:4616
NCBI Accession:NP_056490.2
UniProt Secondary Accession:O75293,O75960, Q17R46, A8KAM2
UniProt Related Accession:O75293
Molecular Weight:17,818 Da
NCBI Full Name:growth arrest and DNA damage-inducible protein GADD45 beta
NCBI Synonym Full Names:growth arrest and DNA-damage-inducible, beta
NCBI Official Symbol:GADD45B��
NCBI Official Synonym Symbols:MYD118; GADD45BETA��
NCBI Protein Information:growth arrest and DNA damage-inducible protein GADD45 beta; negative growth regulatory protein MyD118; myeloid differentiation primary response protein MyD118
UniProt Protein Name:Growth arrest and DNA damage-inducible protein GADD45 beta
UniProt Synonym Protein Names:Myeloid differentiation primary response protein MyD118; Negative growth regulatory protein MyD118
Protein Family:
UniProt Gene Name:GADD45B��
UniProt Entry Name:GA45B_HUMAN
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