Human FZD7 Full-Length Bioactive Membrane Protein (HDFP090)

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SKU:
HDFP090
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
O75084

Description

system_update_altDatasheet
Product nameHuman FZD7 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP090
Product CategoryFull Length Transmembrane Proteins
Target:FZD7
Uniprot:O75084
Description:Human FZD7 full length protein-synthetic nanodisc
Molecular Weight:The human full length FZD7 protein has a MW of 63.4 kDa
Protein Family:Druggable Genome, Transmembrane
Protein Pathways:Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:FzE3
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
Delivery:3-4 weeks
UsageResearch use only
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