Human FZD4 Full-Length Bioactive Membrane Protein (HDFP120)

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SKU:
HDFP120
Product Type:
Recombinant Protein
Protein Type:
Full-Length Bioactive Membrane Protein
Species:
Human
Uniprot:
Q9ULV1

Description

system_update_altDatasheet
Product nameHuman FZD4 full length protein-synthetic nanodisc
Size:10ug
Product SKU:HDFP120
Product CategoryFull Length Transmembrane Proteins
Target:FZD4
Uniprot:Q9ULV1
Description:Human FZD4 full length protein-synthetic nanodisc
Molecular Weight:The human full length FZD4 protein has a MW of 60.3 kDa
Protein Family:Druggable Genome, GPCR, Transmembrane
Protein Pathways:Basal cell carcinoma, Colorectal cancer, Melanogenesis, Pathways in cancer, Wnt signaling pathway
Storage & Shipping:Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Synonyms:CD344; EVR1; FEVR; Fz-4; Fz4; FZD4S; FzE4; GPCR; hFz4
Expression System:HEK293
Formulation:Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Background:A member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.
Delivery:In Stock
UsageResearch use only
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