Human FXYD5 Recombinant Protein (RPPB3564)

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RPPB3564

Description

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Product Name:Human FXYD5 Recombinant Protein
Product Code:RPPB3564
Size:20µg
Species:Human
Target:FXYD5
Synonyms:DYSAD, HSPC113, IWU1, KCT1, OIT2, PRO6241, RIC, FXYD domain-containing ion transport regulator 5, Dysadherin, FXYD5, Keratinocytes Associated Transmembrane Protein 1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FXYD5 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 10% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSQTLKDTT SSSSADSTIM DIQVPTRAPD AVYTELQPTS PTPTWPADET PQPQTQTQQL EGTDGPLVTD PETHKSTKAA HPTDDTTTLS ERPSPSTDVQ TDPQTLKPSG FHEDDPFFYD EHTLRKR

FXYD domain-containing ion transport regulator 5 (FXYD5) is a cancer-associated cell membrane glycoprotein which is a part of the FXYD family. FXYD5 is engaged in down-regulation of E-cadherin, which takes part in tumor development and metastasis and results in reduced cell adhesion.FXYD is found in spleen, lung, skeletal muscle, and testis tissue, and maps to human chromosome 19q13.2.

FXYD5 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 147 amino acids (22-145 a.a) and having a molecular mass of 16.1kDa. FXYD5 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FXYD5: Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. Belongs to the FXYD family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesion; Actin-binding; Membrane protein, integralChromosomal Location of Human Ortholog: 19q13.12Cellular Component: integral to membrane; integral to plasma membraneMolecular Function: actin binding; cadherin binding; sodium channel regulator activity
UniProt Protein Details:
NCBI Summary:This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
UniProt Code:Q96DB9
NCBI GenInfo Identifier:311033386
NCBI Gene ID:53827
NCBI Accession:Q96DB9.2
UniProt Secondary Accession:Q96DB9,Q6UW44, Q9HC34, Q9P039, B7WNZ8
UniProt Related Accession:Q96DB9
Molecular Weight:11,888 Da
NCBI Full Name:FXYD domain-containing ion transport regulator 5
NCBI Synonym Full Names:FXYD domain containing ion transport regulator 5
NCBI Official Symbol:FXYD5��
NCBI Official Synonym Symbols:RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241��
NCBI Protein Information:FXYD domain-containing ion transport regulator 5
UniProt Protein Name:FXYD domain-containing ion transport regulator 5
UniProt Synonym Protein Names:Dysadherin
Protein Family:FXYD domain-containing ion transport regulator
UniProt Gene Name:FXYD5��
UniProt Entry Name:FXYD5_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96DB9
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