Enzymes Recombinant Proteins

Human FUCA2 Recombinant Protein (RPPB1651)

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SKU:
RPPB1651
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9BTY2
Research Area:
Enzymes

Description

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Product Name:Human FUCA2 Recombinant Protein
Product Code:RPPB1651
Size:20µg
Species:Human
Target:FUCA2
Synonyms:Fucosidase,alpha-L- 2, plasma, dJ20N2.5, RP1-20N2.5, Plasma alpha-L-fucosidase, Alpha-L-fucosidefucohydrolase 2, Alpha-L-fucosidase 2, PSEC0151, UNQ227/PRO260.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FUCA2 protein solution (1mg/ml) containing 20mM phosphate(pH8.0) and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHSATRFD PTWESLDARQ LPAWFDQAKF GIFIHWGVFS VPSFGSEWFWWYWQKEKIPK YVEFMKDNYP PSFKYEDFGP LFTAKFFNAN QWADIFQASG AKYIVLTSKH HEGFTLWGSEYSWNWNAIDE GPKRDIVKEL EVAIRNRTDL RFGLYYSLFE WFHPLFLEDE SSSFHKRQFP VSKTLPELYELVNNYQPEVL WSDGDGGAPD QYWNSTGFLA WLYNESPVRG TVVTNDRWGA GSICKHGGFY TCSDRYNPGHLLPHKWENCM TIDKLSWGYR REAGISDYLT IEELVKQLVE TVSCGGNLLM NIGPTLDGTI SVVFEERLRQMGSWLKVNGE AIYETHTWRS QNDTVTPDVW YTSKPKEKLV YAIFLKWPTS GQLFLGHPKA ILGATEVKLLGHGQPLNWIS LEQNGIMVEL PQLTIHQMPC KWGWALALTN VI

Fucosidase Alpha-L- 2 Plasma (FUCA2) is a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. FUCA2 protein belongs to the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose fused to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. FUCA2 is crucial for Helicobacter pylori adhesion to human gastric cancer cells.

FUCA2 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 462 amino acids (29-467 a.a) andhaving a molecular mass of 53.3kDa.FUCA2 is fusedto a 23 amino acid His-tag at N-terminus & purified by proprietarychromatographic techniques.

UniProt Protein Function:FUCA2: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N- acetylglucosamine of the carbohydrate moieties of glycoproteins. Belongs to the glycosyl hydrolase 29 family.
UniProt Protein Details:

Protein type:Secreted; EC 3.2.1.51; Glycan Metabolism - other glycan degradation; Hydrolase; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 6q24

Cellular Component: extracellular space; lysosome

Molecular Function:alpha-L-fucosidase activity; fucose binding

Biological Process: fucose metabolic process; glycoside catabolic process; response to bacterium

NCBI Summary:This gene encodes a plasma alpha-L-fucosidase, which represents 10-20% of the total cellular fucosidase activity. The protein is a member of the glycosyl hydrolase 29 family, and catalyzes the hydrolysis of the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. This enzyme is essential for Helicobacter pylori adhesion to human gastric cancer cells. [provided by RefSeq, Aug 2010]
UniProt Code:Q9BTY2
NCBI GenInfo Identifier:254763296
NCBI Gene ID:2519
NCBI Accession:Q9BTY2.2
UniProt Related Accession:Q9BTY2
Molecular Weight:77.7 kDa
NCBI Full Name:Plasma alpha-L-fucosidase
NCBI Synonym Full Names:alpha-L-fucosidase 2
NCBI Official Symbol:FUCA2��
NCBI Official Synonym Symbols:dJ20N2.5��
NCBI Protein Information:plasma alpha-L-fucosidase
UniProt Protein Name:Plasma alpha-L-fucosidase
UniProt Synonym Protein Names:Alpha-L-fucoside fucohydrolase 2; Alpha-L-fucosidase 2
Protein Family:Plasma alpha-L-fucosidase
UniProt Gene Name:FUCA2��
UniProt Entry Name:FUCO2_HUMAN
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