Human FRZB/sFRP-3 Recombinant Protein (RPES3816)

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SKU:
RPES3816
Product Type:
Recombinant Protein
Species:
Human

Description

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Human FRZB/sFRP-3 Recombinant Protein

FRZB also known as sFRP-3, is a secreted protein containing a domain similar to the putative Wnt-binding region of the frizzled family of transmembrane receptors. FRZB is widely expressed in adult mammalian tissues. In the Xenopus gastrula, FRZB is regulated as a typical Spemann organizer component. FRZB also functions as a competitor for the cell-surface G-protein receptor Frizzled. It is espically important in embryonic development. Defects in FRZB gene can cause female-specific osteoarthritis (OA) susceptibility. FRZB may serve an important role in determining hip shape and may modify the relationship between hip shape and OA.

Product Name:Human FRZB/sFRP-3 Recombinant Protein (RPES3816)
Product Code:RPES3816
Size:20µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:FRE,FRITZ,FRP-3,FRZB-1,FRZB-PEN,FRZB1,FZRB,hFIZ,OS1,SFRP3,SRFP3
Accession:NP_001454.2
Sequence:Ala32-Asn325
Fusion tag:C-His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human FRZB (NP_001454.2) (Ala32-Asn325) was expressed with a C-terminal polyhistidine tag.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:34.5 kDa
AP Mol Mass:41 kDa
Formulation:Lyophilized from sterile PBS, pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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