Human Frizzled-6/FZD6 Recombinant Protein (RPES3481)

(No reviews yet) Write a Review
SKU:
RPES3481
Product Type:
Recombinant Protein
Species:
Human

Description

system_update_altDatasheet

Human Frizzled-6/FZD6 Recombinant Protein

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.

View AllClose

0 Reviews

View AllClose