Human Follistatin/FST Recombinant Protein (RPES1556)

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SKU:
RPES1556
Product Type:
Recombinant Protein
Species:
Human

Description

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Human Follistatin/FST Recombinant Protein

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms; FST317 and FST344 containing 317 and 344 amino acids respectively; resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families; evidence was found for linkage between PCOS and follistatin. follistatin are expressed and subserve local regulatory roles in numerous extragonadal tissues; including brain; adrenal; bone marrow; and placenta but perhaps most notably in anterior pituitary-the classical target tissue for inhibin; the activin-follistatin system may play a key role in early embryogenesis. Follistatin binds directly to activin and functions as an activin antagonist. Specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone follistatin is a binding protein to activin. Since activin binds to follistatin; it is imperative to determine the nature of the activin/follistatin binding complex.

Product Name:Human Follistatin/FST Recombinant Protein (RPES1556)
Product Code:RPES1556
Size:20µg
Species:Human
Expressed Host:HEK293 Cells
Synonyms:FS
Accession:NP_037541.1
Sequence:Met 1-Trp 344
Fusion tag:C-Fc
Activity:1. Measured by its ability to bind human INHBA-his in a functional ELISA.2. Measured by its ability to bind mouse INHBA-his in a functional ELISA.3. Measured by its ability to neutralize Activin-mediated inhibition on MPC11 cell proliferation. The ED50 for this effect is typically 0.5-3 µg/mL in the presence of 10 ng/ml Recombinant Human ctivin A.
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:A DNA sequence encoding the human FST isoform FST344 (NP_037541.1) (Met 1-Trp 344) was fused with the Fc region of human IgG1 at the C-terminus.
Purity:> 85 % as determined by reducing SDS-PAGE.
Mol Mass:61.7 kDa
AP Mol Mass:70 kDa
Formulation:Lyophilized from sterile PBS; pH 7.4
Shipping:This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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