Human FNDC5 Recombinant Protein (RPPB3549)

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SKU:
RPPB3549
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q8NAU1

Description

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Product Name:Human FNDC5 Recombinant Protein
Product Code:RPPB3549
Size:10µg
Species:Human
Target:FNDC5
Synonyms:Fibronectin type III domain-containing protein 5, Fibronectin type III repeat-containing protein, Fibronectin Type III Repeat-Containing Protein 2, Irisin, FNDC5, FRCP2.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:FNDC5 filtered (0.4 �m) and lyophilized from 0.5mg/ml in phosphate buffered saline.
Solubility:It is recommended to add 200�l deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. FNDC5 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHASDSPSAPVNVT VRHLKANSAV VSWDVLEDEV VIGFAISQQK KDVRMLRFIQ EVNTTTRSCA LWDLEEDTEY IVHVQAISIQ GQSPASEPVL FKTPREAEKM ASKNKDEVTM KE

Fibronectin Type III Domain Containing 5 (Irisin) is a newly discovered hormone, secreted into circulation by muscle, which acts on white adipocytes and promotes WAT �browning�. r-Irisin can reduce body weight and cause induction of brown adipocyte in vivo, including a capacity for thermogenic energy expenditure mediated by uncoupling protein 1 (UCP-1). Irisin mature protein is comprised of 110 amino acid residues and two potential glycosylation sites. High levels of Irisin can be found in the heart whereas Very low expression is found in the colon, pancreas and spleen, if any.

FNDC5 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 32-143) containing 122 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 13.8kDa (calculated).

UniProt Protein Function:FNDC5: Irisin: mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p35.1

Cellular Component: endoplasmic reticulum; extracellular region; plasma membrane

Biological Process: response to muscle activity

NCBI Summary:This gene encodes a secreted protein that is released from muscle cells during exercise. The encoded protein may participate in the development of brown fat. Translation of the precursor protein initiates at a non-AUG start codon at a position that is conserved as an AUG start codon in other organisms. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
UniProt Code:Q8NAU1
NCBI GenInfo Identifier:403314395
NCBI Gene ID:252995
NCBI Accession:Q8NAU1.3
UniProt Secondary Accession:Q8NAU1,Q6P6D9, Q7Z676, A6NMC9, D3DPQ6,
UniProt Related Accession:Q8NAU1
Molecular Weight:23659 Da
NCBI Full Name:Fibronectin type III domain-containing protein 5
NCBI Synonym Full Names:fibronectin type III domain containing 5
NCBI Official Symbol:FNDC5��
NCBI Official Synonym Symbols:FRCP2; irisin��
NCBI Protein Information:fibronectin type III domain-containing protein 5
UniProt Protein Name:Fibronectin type III domain-containing protein 5
UniProt Synonym Protein Names:Fibronectin type III repeat-containing protein 2
Protein Family:Fibronectin type III domain-containing protein
UniProt Gene Name:FNDC5��
UniProt Entry Name:FNDC5_HUMAN
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