Immune Checkpoint Recombinant Proteins

Human FLT3 Recombinant Protein (hFc-His Tag) (HDPT0007)

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SKU:
HDPT0007
Product Type:
Recombinant Protein
Species:
Human
Research Area:
Immune Checkpoint

Description

Human FLT3 Recombinant Protein (hFc-His Tag)

Description:Flt-3(Receptor-type tyrosine-protein kinase FLT3) is also known as FLK-2(Fetal liver kinase-2), STK-1(Stem cell tyrosine kinase 1), CD135. FLT3 is a cytokine receptor which belongs to the receptor tyrosine kinase class III. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways.
Product name:Human FLT3 Recombinant Protein (hFc-His Tag)
Synonyms:Flt-3, Flk-2, STK-1, CD135, FLK2, FLT-3
Type:protein
Size:50 µg
Name:FLT3
Origin:Human
Source:HEK293
Protein Type:Recombinant
Application:ELISA
Purity:> 95%
Purification:affinity purification
Format:Lyophilized
Conjugate:C-Human Fc and 6×His tag
Storage:Store at -80°C for 12 months (Avoid repeated freezing and thawing)
Usage:Research use only
Buffer:Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Reconstitution:Reconstitute with deionized water
Sequence:FLT3(Asn27-Ser543)+hFc(Glu99-Ala330)+6×His tag
Gene ID:2322
Uniprot:P36888
Molecular Weight:125-130 kDa
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