Human FLRT3 Recombinant Protein (RPPB3548)

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SKU:
RPPB3548
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9NZU0

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human FLRT3 Recombinant Protein
Product Code:RPPB3548
Size:10µg
Species:Human
Target:FLRT3
Synonyms:FibronectinLeucine Rich Transmembrane Protein 3, Fibronectin-Like Domain, Containing Leucine-Rich Transmembrane Protein 3, HH21, Leucine-Rich Repeat, Transmembrane Protein FLRT3,KIAA1469.
Source:Sf9 Insect cells
Physical Appearance:Sterilefiltered colorless solution.
Formulation:FLRT3protein solution (1mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10%glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greaterthan 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:KSCPSVCRCD AGFIYCNDRF LTSIPTGIPE DATTLYLQNN QINNAGIPSDLKNLLKVERI YLYHNSLDEF PTNLPKYVKE LHLQENNIRT ITYDSLSKIP YLEELHLDDN SVSAVSIEEGAFRDSNYLRL LFLSRNHLST IPWGLPRTIE ELRLDDNRIS TISSPSLQGL TSLKRLVLDG NLLNNHGLGDKVFFNLVNLT ELSLVRNSLT AAPVNLPGTN LRKLYLQDNH INRVPPNAFS YLRQLYRLDM SNNNLSNLPQGIFDDLDNIT QLILRNNPWY CGCKMKWVRD WLQSLPVKVN VRGLMCQAPE KVRGMAIKDL NAELFDCKDSGIVSTIQITT AIPNTVYPAQ GQWPAPVTKQ�PDIKNPKLTK DHQTTGSPSRKTITITVKSV TSDTIHISWK LALPMTALRL SWLKLGHSPA FGSITETIVT GERSEYLVTA LEPDSPYKVC MVPMETSNLYLFDETPVCIE TETAPLRMYN PTTTLNREQE KEPYKNPNLP LEHHHHHH

Fibronectin Leucine Rich Transmembrane Protein3, also known as FLRT3 is a member of the fibronectin leucine richtransmembrane protein (FLRT) family. FLRT3 contains one fibronectin type-IIIdomain as well as 10 LRR (leucine-rich) repeats and is expressed in the kidney,brain, pancreas, skeletal muscle, lung, liver, placenta, and heart.� In addition, the members of the FLRT familyplay a role in cell adhesion as well as receptor signaling. FLRT3 has beenimplicated in neurite outgrowth after nerve damage, as a positive regulator ofFGF signalling and in homotypic cell adhesion. Furthermore, FLRT3 has an essentialfunction in regulating cellular adhesion among the epithelial apical ridge andthe underlying mesenchyme and also in the establishment of the dorso-ventralposition of the ridge.

FLRT3 produced in Sf9 insect cells is a single,glycosylated polypeptide chain containing 508 amino acids (29-528a.a.) andhaving a molecular mass of 57.6kDa. (Molecular size on SDS-PAGE will appear atapproximately 70-100kDa).FLRT3 is expressed with an 8 amino acid His tag atC-Terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:FLRT3: May have a function in cell adhesion and/or receptor signaling.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 20p11

Cellular Component: cytoplasm; integral to plasma membrane; nerve terminal; plasma membrane

Molecular Function:protein binding; protein homodimerization activity; protein kinase inhibitor activity

Biological Process: cytokine and chemokine mediated signaling pathway; embryonic morphogenesis; fibroblast growth factor receptor signaling pathway; heart development; negative regulation of JAK-STAT cascade; negative regulation of protein kinase activity; neurite development; response to axon injury; synaptogenesis

Disease: Hypogonadotropic Hypogonadism 21 With Or Without Anosmia

UniProt Code:Q9NZU0
NCBI GenInfo Identifier:7019383
NCBI Gene ID:23767
NCBI Accession:NP_037413.1
UniProt Secondary Accession:Q9NZU0,Q542Z9, Q96K39, Q96K42, Q96KB1, Q9P259, D3DW20
UniProt Related Accession:Q9NZU0
Molecular Weight:73,004 Da
NCBI Full Name:leucine-rich repeat transmembrane protein FLRT3
NCBI Synonym Full Names:fibronectin leucine rich transmembrane protein 3
NCBI Official Symbol:FLRT3��
NCBI Official Synonym Symbols:HH21��
NCBI Protein Information:leucine-rich repeat transmembrane protein FLRT3
UniProt Protein Name:Leucine-rich repeat transmembrane protein FLRT3
UniProt Synonym Protein Names:Fibronectin-like domain-containing leucine-rich transmembrane protein 3
Protein Family:Leucine-rich repeat transmembrane protein
UniProt Gene Name:FLRT3��
UniProt Entry Name:FLRT3_HUMAN
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