Human FLRT2 Recombinant Protein (RPPB3547)

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SKU:
RPPB3547
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O43155

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human FLRT2 Recombinant Protein
Product Code:RPPB3547
Size:5µg
Species:Human
Target:FLRT2
Synonyms:Leucine-rich repeat transmembrane protein FLRT2, Fibronectin-like domain-containing leucine-rich transmembrane protein 2, KIAA0405, UNQ232/PRO265.
Source:Sf9 Insect cells
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The FLRT2 solution (0.25mg/1ml) contains 10% glycerol and Phosphate-Buffered Saline (pH 7.4).
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:CPSVCRCDRN FVYCNERSLT SVPLGIPEGV TVLYLHNNQI NNAGFPAELH NVQSVHTVYL YGNQLDEFPM NLPKNVRVLH LQENNIQTIS RAALAQLLKL EELHLDDNSI STVGVEDGAF REAISLKLLF LSKNHLSSVP VGLPVDLQEL RVDENRIAVI SDMAFQNLTS LERLIVDGNL LTNKGIAEGT FSHLTKLKEF SIVRNSLSHP PPDLPGTHLI RLYLQDNQIN HIPLTAFSNL RKLERLDISN NQLRMLTQGV FDNLSNLKQL TARNNPWFCD CSIKWVTEWL KYIPSSLNVR GFMCQGPEQV RGMAVRELNM NLLSCPTTTP GLPLFTPAPS TASPTTQPPT LSIPNPSRSY TPPTPTTSKL PTIPDWDGRE RVTPPISERI QLSIHFVNDT SIQVSWLSLF TVMAYKLTWV KMGHSLVGGI VQERIVSGEK QHLSLVNLEP RSTYRICLVP LDAFNYRAVE DTICSEATTH ASYLNNGSNT ASSHEQTTSH SMGSPFLEHH HHHH

Fibronectin Leucine Rich Transmembrane Protein 2 or FLRT2 is a glycoprotein, part of the 3 FLRT glycoproteins (fibronectin, leucine rich repeat, transmembrane). This protein can be found in apparent areas of the brain and additional tissues. The genes of FLRT1 & FLRT3 extracellular domain has about 47% similarity to FLRT2. A domain of fibronectin in FLRT1, FLRT3 & FLRT2 can be bound to epidermal growth factor receptors.

FLRT2 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 514 amino acids (36-541 a.a) and having a molecular mass of 57.5kDa.FLRT2 is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis.
NCBI Summary:This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
UniProt Code:O43155
NCBI GenInfo Identifier:1071034772
NCBI Gene ID:23768
NCBI Accession:NP_001333072.1
UniProt Secondary Accession:O43155,A0AV84, B7ZLP3,
UniProt Related Accession:O43155
Molecular Weight:Molecular Mass: 57.3kDaActual Protein�Molecular Mass: 78kDa
NCBI Full Name:leucine-rich repeat transmembrane protein FLRT2
NCBI Synonym Full Names:fibronectin leucine rich transmembrane protein 2
NCBI Official Symbol:FLRT2��
NCBI Protein Information:leucine-rich repeat transmembrane protein FLRT2
UniProt Protein Name:Leucine-rich repeat transmembrane protein FLRT2
UniProt Synonym Protein Names:Fibronectin-like domain-containing leucine-rich transmembrane protein 2
Protein Family:Leucine-rich repeat transmembrane protein
UniProt Gene Name:FLRT2��
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