Enzymes Recombinant Proteins

Human FKBPL Recombinant Protein (RPPB1647)

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SKU:
RPPB1647
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UIM3
Research Area:
Enzymes

Description

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Product Name:Human FKBPL Recombinant Protein
Product Code:RPPB1647
Size:5µg
Species:Human
Target:FKBPL
Synonyms:WISP39, DIR1, NG7, FK506-binding protein-like, WAF-1/CIP1 stabilizing protein 39, FKBPL.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:FKBPL Human solution containing 20mM Trsi pH-8, 2mM DTT, 0.1M NaCl & 20% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:METPPVNTIG EKDTSQPQQE WEKNLRENLD SVIQIRQQPR DPPTETLELE VSPDPASQIL EHTQGAEKLV AELEGDSHKS HGSTSQMPEA LQASDLWYCP DGSFVKKIVI RGHGLDKPKL GSCCRVLALG FPFGSGPPEG WTELTMGVGP WREETWGELI EKCLESMCQG EEAELQLPGH SGPPVRLTLA SFTQGRDSWE LETSEKEALA REERARGTEL FRAGNPEGAA RCYGRALRLL LTLPPPGPPE RTVLHANLAA CQLLLGQPQL AAQSCDRVLE REPGHLKALY RRGVAQAALG NLEKATADLK KVLAIDPKNR AAQEELGKVV IQGKNQDAGL AQGLRKMFGL EHHHHHH
Biological Activity:Specific activity is > 210 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

FKBPL is related to the immunophilin protein family, which take part in immunoregulation and regular cellular processes involving protein folding and trafficking. FKBPL has an important function in the induced radioresistance and participates in the control of the cell cycle. FKBPL has a role in cellular response to stress. FKBPL interacts with Hsp90, glucocorticoid receptor and dynamitin and is involved in signalling, like other FKBPs.

FKBPL Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 357 amino acids (1-349 a.a.) and having a molecular mass of 39.2 kDa. The FKBPL is fused to an 8 amino acid His-Tag at C-terminus and purified by proprietary chromatographic techniques.

UniProt Protein Function:FKBPL: May be involved in response to X-ray. Regulates p21 protein stability by binding to Hsp90 and p21.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: cytosol; endoplasmic reticulum membrane

Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

Biological Process: protein stabilization

NCBI Summary:The protein encoded by this gene has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UIM3
NCBI GenInfo Identifier:74762773
NCBI Gene ID:63943
NCBI Accession:Q9UIM3.1
UniProt Secondary Accession:Q9UIM3,Q9H5G3, A8K5V3, B0UYX8,
UniProt Related Accession:Q9UIM3
Molecular Weight:38,176 Da
NCBI Full Name:FK506-binding protein-like
NCBI Synonym Full Names:FK506 binding protein like
NCBI Official Symbol:FKBPL��
NCBI Official Synonym Symbols:NG7; DIR1; FKBP4; WISP39��
NCBI Protein Information:FK506-binding protein-like
UniProt Protein Name:FK506-binding protein-like
UniProt Synonym Protein Names:WAF-1/CIP1 stabilizing protein 39; WISp39
Protein Family:FK506-binding protein
UniProt Gene Name:FKBPL��
UniProt Entry Name:FKBPL_HUMAN
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