Human FKBP3/FKBP25 Recombinant Protein (RPES1583)

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SKU:
RPES1583
Product Type:
Recombinant Protein
Species:
Human

Description

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Human FKBP3/FKBP25 Recombinant Protein

FKBP25 contains 1 PPIase FKBP-type domain; belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin; as well as histone deacetylases; the transcription factor YY1; casein kinase II; and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin.

Product Name:Human FKBP3/FKBP25 Recombinant Protein (RPES1583)
Product Code:RPES1583
Size:10µg
Species:Human
Expressed Host:E.coli
Synonyms:Peptidyl-prolyl cis-trans isomerase FKBP3,PPIase FKBP3,25 kDa FK506-binding protein,25 kDa FKBP,FKBP-25,FK506-binding protein 3,FKBP-3,Immunophilin FKBP25,Rapamycin-selective 25 kDa immunophilin,Rotamase,FKBP25
Accession:Q00688
Sequence:Met 1-Asp224
Fusion tag:N-6His
Endotoxin:<1.0 EU per µg as determined by the LAL method.
Protein Construction:Recombinant Human 25 kDa FK506-binding protein is produced by our E.coli expression system and the target gene encoding Met1-Asp224 is expressed with a 6His tag at the N-terminus.
Purity:> 95 % as determined by reducing SDS-PAGE.
Mol Mass:27.3 kDa
AP Mol Mass:30 kDa
Formulation:Supplied as a 0.2 µm filtered solution of 20mM TrisHCl;1mM DTT;10% glycerol .
Shipping:This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs.Upon receipt; store it immediately at<-20°C.
Stability and Storage:Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
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