Enzymes Recombinant Proteins

Human FKBP2 Recombinant Protein (RPPB1642)

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RPPB1642

Description

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Product Name:Human FKBP2 Recombinant Protein
Product Code:RPPB1642
Size:10µg
Species:Human
Target:FKBP2
Synonyms:FKBP13, FKBP-2, Peptidyl-prolyl cis-trans isomerase FKBP2, PPIase FKBP2, FK506-binding protein 2, Rotamase, Immunophilin FKBP13, 13 kDa FK506-binding protein, 13 kDa FKBP, FKBP-13, FKBP2, PPIase.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear colorless solution.
Formulation:The FKBP2 solution contains 20mM Tris-HCl pH-8, 1mM DTT, and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MATGAEGKRK LQIGVKKRVD HCPIKSRKGD VLHMHYTGKL EDGTEFDSSL PQNQPFVFSL GTGQVIKGWD QGLLGMCEGE KRKLVIPSEL GYGERGAPPK IPGGATLVFE VELLKIERRT EL
Biological Activity:Specific activity is > 270 nmoles/min/ug, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

FKBP2 is part of the immunophilin protein family, which takes part in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP2 is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. FKBP2 functions as an ER chaperone and as a component of membrane cytoskeletal scaffolds.

FKBP2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 122 amino acids (22-142 a.a.) and having a molecular mass of 13.4 kDa. The FKBP2 is purified by proprietary chromatographic techniques.

UniProt Protein Function:FKBP2: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP2 subfamily.
UniProt Protein Details:

Protein type:EC 5.2.1.8; Endoplasmic reticulum; Isomerase

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: endoplasmic reticulum

Molecular Function:FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding

NCBI Summary:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is thought to function as an ER chaperone and may also act as a component of membrane cytoskeletal scaffolds. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]
UniProt Code:P26885
NCBI GenInfo Identifier:23503054
NCBI Gene ID:2286
NCBI Accession:P26885.2
UniProt Secondary Accession:P26885,Q5BJH9, Q9BTS7,
UniProt Related Accession:P26885
Molecular Weight:16kDa
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP2
NCBI Synonym Full Names:FK506 binding protein 2
NCBI Official Symbol:FKBP2��
NCBI Official Synonym Symbols:PPIase; FKBP-13��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP2
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP2
UniProt Synonym Protein Names:13 kDa FK506-binding protein; 13 kDa FKBP; FKBP-13; FK506-binding protein 2; FKBP-2; Immunophilin FKBP13; Rotamase
Protein Family:FK506-binding protein
UniProt Gene Name:FKBP2��
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P26885
Research Area:
Enzymes
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