Enzymes Recombinant Proteins

Human FKBP1B Recombinant Protein (RPPB1641)

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SKU:
RPPB1641
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P68106
Research Area:
Enzymes

Description

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Product Name:Human FKBP1B Recombinant Protein
Product Code:RPPB1641
Size:20µg
Species:Human
Target:FKBP1B
Synonyms:Peptidyl-prolyl cis-trans isomerase FKBP1B, PPIase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FKBP-12.6, FK506-binding protein 1B, FKBP-1B, Immunophilin FKBP12.6, Rotamase, h-FKBP-12, FKBP1B, FKBP12.6, FKBP1L, FKBP9, OTK4.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:The FKBP1B solution (0.25mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE analysis.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH RSMGVEIETI SPGDGRTFPK KGQTCVVHYT GMLQNGKKFD SSRDRNKPFK FRIGKQEVIK GFEEGAAQMS LGQRAKLTCT PDVAYGATGH PGVIPPNATL IFDVELLNLE
Biological Activity:Specific activity is > 300 nmoles/min/mg, and is defined as the amount of enzyme that cleaves 1umole of suc-AAFP-pNA per minute at 25C in Tris-Hcl pH8.0 using chymotrypsin.

Peptidyl-prolyl cis-trans isomerase FKBP1B (FKBP1B) belongs to the immunophilin protein family which has a role in immunoregulation and basic cellular processes involving protein folding and trafficking. FKBP1B is a cis-trans prolyl isomerase which binds the immunosuppressants FK506 and rapamycin. FKBP1B is extremely similar to the FK506-binding protein 1A. The physiological role of FKBP1B is thought to be in excitation-contraction coupling in cardiac muscle.

FKBP1B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 130 amino acids (1-108) and having a molecular mass of 14.2kDa.FKBP1B is fused to a 22 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: cytoplasm; cytosol; membrane; sarcoplasmic reticulum membrane; Z disc

Molecular Function:calcium channel inhibitor activity; FK506 binding; peptidyl-prolyl cis-trans isomerase activity; protein binding; receptor binding; ryanodine-sensitive calcium-release channel activity

Biological Process: 'de novo' protein folding; cytosolic calcium ion homeostasis; negative regulation of heart rate; negative regulation of protein phosphatase type 2B activity; negative regulation of release of sequestered calcium ion into cytosol; positive regulation of sequestering of calcium ion; protein maturation via protein folding; protein peptidyl-prolyl isomerization; protein refolding; response to redox state

NCBI Summary:The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]
UniProt Code:P68106
NCBI GenInfo Identifier:61224185
NCBI Gene ID:2281
NCBI Accession:P68106.2
UniProt Secondary Accession:P68106,Q13664, Q16645, Q53TM2, Q9BQ40,
UniProt Related Accession:P68106
Molecular Weight:8,802 Da
NCBI Full Name:Peptidyl-prolyl cis-trans isomerase FKBP1B
NCBI Synonym Full Names:FK506 binding protein 1B
NCBI Official Symbol:FKBP1B��
NCBI Official Synonym Symbols:OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6��
NCBI Protein Information:peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Protein Name:Peptidyl-prolyl cis-trans isomerase FKBP1B
UniProt Synonym Protein Names:12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12
Protein Family:Peptidyl-prolyl cis-trans isomerase
UniProt Gene Name:FKBP1B��
UniProt Entry Name:FKB1B_HUMAN
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