Human FIS1 Recombinant Protein (RPPB3545)
- SKU:
- RPPB3545
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9Y3D6
Description
| Product Name: | Human FIS1 Recombinant Protein |
| Product Code: | RPPB3545 |
| Size: | 25µg |
| Species: | Human |
| Target: | FIS1 |
| Synonyms: | TTC11, Tetratricopeptide repeat domain 11, Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae). |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile filtered colorless solution. |
| Formulation: | FIS1 protein solution (1mg/ml) containing 20mM Tris-HCl pH-8 and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG |
FIS1 is part of the mitochondrial complex that promotes mitochondrial fission. FIS1 induces cytochrome C discharge from the mitochondrion to the cytosol, eventually leading to apoptosis. FIS1 participates in peroxisomal growth and division. The C terminus is required for mitochondrial localisation, while the N teminus is necessary for mitochondrial fission.
FIS1 Human Recombinant produced in E.Coli is a single, non-glycosylated,polypeptide chain containing 142 amino acids (1-122 a.a.) and having a molecular mass of 16.3 kDa. FIS1 protein is fused to a 20 amino acid His tag at N-terminus and is purified by standard chromatography.
| UniProt Protein Function: | FIS1: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. Belongs to the FIS1 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: integral to mitochondrial outer membrane; integral to peroxisomal membrane; membrane; mitochondrion; peroxisome; protein complex Molecular Function:protein binding; receptor binding Biological Process: elevation of cytosolic calcium ion concentration; elevation of mitochondrial calcium ion concentration; mitochondrial fission; mitochondrial fragmentation during apoptosis; mitochondrial fusion; mitochondrion degradation; peroxisome fission; positive regulation of caspase activity; protein homooligomerization; protein targeting to mitochondrion; reduction of endoplasmic reticulum calcium ion concentration; release of cytochrome c from mitochondria |
| NCBI Summary: | The balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission (James et al., 2003 [PubMed 12783892]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q9Y3D6 |
| NCBI GenInfo Identifier: | 33112470 |
| NCBI Gene ID: | 51024 |
| NCBI Accession: | Q9Y3D6.2 |
| UniProt Secondary Accession: | Q9Y3D6,Q9BTP3, |
| UniProt Related Accession: | Q9Y3D6 |
| Molecular Weight: | 16,938 Da |
| NCBI Full Name: | Mitochondrial fission 1 protein |
| NCBI Synonym Full Names: | fission, mitochondrial 1 |
| NCBI Official Symbol: | FIS1�� |
| NCBI Official Synonym Symbols: | TTC11; CGI-135�� |
| NCBI Protein Information: | mitochondrial fission 1 protein |
| UniProt Protein Name: | Mitochondrial fission 1 protein |
| UniProt Synonym Protein Names: | FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 |
| Protein Family: | Mitochondria fission 1 protein |
| UniProt Gene Name: | FIS1�� |
| UniProt Entry Name: | FIS1_HUMAN |
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