Human FGL1 Recombinant Protein (RPPB3538)
- SKU:
- RPPB3538
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q08830
Description
| Product Name: | Human FGL1 Recombinant Protein |
| Product Code: | RPPB3538 |
| Size: | 10µg |
| Species: | Human |
| Target: | FGL1 |
| Synonyms: | Fibrinogen-like protein 1, HP-041, Hepassocin, Hepatocyte-derived fibrinogen-related protein 1, HFREP-1, Liver fibrinogen-related protein 1, LFIRE-1, FGL1, HFREP1. |
| Source: | Escherichia Coli |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | FGL1 filtered (0.4 �m) and lyophilized from 0.5mg/ml in in 100 mM carbonate buffer, pH 9.2. |
| Solubility: | It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. FGL1 is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MKHHHHHHAS LEDCAQEQMR LRAQVRLLET RVKQQQVKIK QLLQENEVQF LDKGDENTVI DLGSKRQYAD CSEIFNDGYK LSGFYKIKPL QSPAEFSVYC DMSDGGGWTV IQRRSDGSEN FNRGWKDYEN GFGNFVQKHG EYWLGNKNLH FLTTQEDYTL KIDLADFEKN SRYAQYKNFK VGDEKNFYEL NIGEYSGTAG DSLAGNFHPE VQWWASHQRM KFSTWDRDHD NYEGNCAEED QSGWWFNRCH SANLNGVYYS GPYTAKTDNG IVWYTWHGWW YSLKSVVMKI RPNDFIPNVI |
FGL1 belongs to the fibrinogen family. Fibrinogen Like 1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which comprises the 4 conserved cysteines of fibrinogens and fibrinogen related proteins. FGL1 lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. Fibrinogen takes part in the development of hepatocellular carcinomas.
FGL1 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 23-312) containing 300 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 35.3kDa (calculated).
| UniProt Protein Function: | FGL1: Has hepatocyte mitogenic activity. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 8p22 Cellular Component: fibrinogen complex Biological Process: cholesterol metabolic process |
| NCBI Summary: | Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved cysteines of fibrinogens and fibrinogen related proteins. However, this protein lacks the platelet-binding site, cross-linking region and a thrombin-sensitive site which are necessary for fibrin clot formation. This protein may play a role in the development of hepatocellular carcinomas. Four alternatively spliced transcript variants encoding the same protein exist for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q08830 |
| NCBI GenInfo Identifier: | 147744562 |
| NCBI Gene ID: | 2267 |
| NCBI Accession: | Q08830.3 |
| UniProt Secondary Accession: | Q08830,Q4PJH9, Q53YF1, Q8NG32, Q96KW6, Q96QM6, A6NKU4 |
| UniProt Related Accession: | Q08830 |
| Molecular Weight: | 312 |
| NCBI Full Name: | Fibrinogen-like protein 1 |
| NCBI Synonym Full Names: | fibrinogen-like 1 |
| NCBI Official Symbol: | FGL1�� |
| NCBI Official Synonym Symbols: | HFREP1; HP-041; LFIRE1; LFIRE-1�� |
| NCBI Protein Information: | fibrinogen-like protein 1; hepassocin; liver fibrinogen-related protein 1; hepatocellular carcinoma-related sequence; hepatocyte-derived fibrinogen-related protein 1 |
| UniProt Protein Name: | Fibrinogen-like protein 1 |
| UniProt Synonym Protein Names: | HP-041; Hepassocin; Hepatocyte-derived fibrinogen-related protein 1; HFREP-1; Liver fibrinogen-related protein 1; LFIRE-1 |
| Protein Family: | Fibrinogen-like protein |
| UniProt Gene Name: | FGL1�� |
| UniProt Entry Name: | FGL1_HUMAN |
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