Growth Factors & Cytokines Recombinant Proteins

Human FGF4 Recombinant Protein (RPPB5729)

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SKU:
RPPB5729
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P08620
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human FGF4 Recombinant Protein
Product Code:RPPB5729
Size:25µg
Species:Human
Target:FGF4
Synonyms:HBGF4, FGF-4, FGF4, KFGF, HSTF1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation:The FGF4 protein was lyophilized with 2xPBS, pH 7.4.
Solubility:It is recommended to reconstitute the lyophilized FGF4 Human Recombinant sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions.
Stability:Lyophilized FGF4 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution FGF-4 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:GRGGAAAPTA PNGTLEAELE RRWESLVALS LARLPVAAQP KEAAVQSGAG DYLLGIKRLR RLYCNVGIGF HLQALPDGRI GGAHADTRDS LLELSPVERG VVSIFGVASR FFVAMSSKGK LYGSPFFTDE CTFKEILLPN NYNAYESYKY PGMFIALSKN GKTKKGNRVS PTMKVTHFLP RL
Biological Activity:The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ?0.5ng/ml, corresponding to a specific activity of ? 2,000,000units/mg.

FGF4 holds s comprehensive mitogenic and cell survival activities and takes part in a range of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF4 possess oncogenic transforming activity. FGF4 and FGF3, oncogenic growth factors are localized on chromosome 11. Co-amplification of both factors was found in several kinds of human tumors. FGF4 functions in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway.

FGF4 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 182 amino acids and having a molecular mass of 19.8kDa.The FGF4 is purified by proprietary chromatographic techniques.

UniProt Protein Function:Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.
NCBI Summary:The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008]
UniProt Code:P08620
NCBI GenInfo Identifier:122750
NCBI Gene ID:2249
NCBI Accession:P08620.1
UniProt Secondary Accession:P08620,B7U994,
UniProt Related Accession:P08620,AAB21430
Molecular Weight:12,237 Da
NCBI Full Name:Fibroblast growth factor 4
NCBI Synonym Full Names:fibroblast growth factor 4
NCBI Official Symbol:FGF4��
NCBI Official Synonym Symbols:HST; KFGF; HST-1; HSTF1; K-FGF; HBGF-4��
NCBI Protein Information:fibroblast growth factor 4; FGF-4; HSTF-1; oncogene HST; kaposi sarcoma oncogene; transforming protein KS3; heparin-binding growth factor 4; heparin secretory transforming protein 1; heparin secretory-transforming protein 1; fibroblast growth factor 4 splice isoform; human stomach cancer, transforming factor from FGF-related oncogene
UniProt Protein Name:Fibroblast growth factor 4
UniProt Synonym Protein Names:Heparin secretory-transforming protein 1; HST; HST-1; HSTF-1; Heparin-binding growth factor 4; HBGF-4; Transforming protein KS3
Protein Family:Fibroblast growth factor
UniProt Gene Name:FGF4��
UniProt Entry Name:FGF4_HUMAN
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