Growth Factors & Cytokines Recombinant Proteins

Human FGF17 Recombinant Protein (RPPB0232)

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SKU:
RPPB0232
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60258
Research Area:
Growth Factors & Cytokines

Description

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Product Name:Human FGF17 Recombinant Protein
Product Code:RPPB0232
Size:25µg
Species:Human
Target:FGF17
Synonyms:Fibroblast growth factor 17, FGF-17, FGF17, FGF-13, HH20.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FGF17 protein solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M urea and 10% glycerol.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMTQGEN HPSPNFNQYV RDQGAMTDQL SRRQIREYQL YSRTSGKHVQ VTGRRISATA EDGNKFAKLI VETDTFGSRV RIKGAESEKY ICMNKRGKLI GKPSGKSKDC VFTEIVLENN YTAFQNARHE GWFMAFTRQG RPRQASRSRQ NQREAHFIKR LYQGQLPFPN HAEKQKQFEF VGSAPTRRTK RTRRPQPLT

Fibroblast Growth Factor 17 (FGF17) belongs to the fibroblast growth factor (FGF) family. FGF family members have broad mitogenic and cell survival activities, and are involved in various biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. The FGF17 gene is highly expressed in the cerebellum and cortex. The mouse homolog of the FGF17 gene is localized to specific sites in the midline structures of the forebrain, the midbrain-hindbrain junction, developing skeleton and developing arteries, suggesting a role in central nervous system, bone and vascular development.

FGF17 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 219 amino acids (23-216 a.a) and having a molecular mass of 25.2kDa.FGF17 is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FGF17: Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide; Cytokine

Chromosomal Location of Human Ortholog: 8p21

Cellular Component: extracellular region; extracellular space

Molecular Function:1-phosphatidylinositol-3-kinase activity; phosphatidylinositol-4,5-bisphosphate 3-kinase activity; protein-tyrosine kinase activity; Ras guanyl-nucleotide exchange factor activity; type 1 fibroblast growth factor receptor binding; type 2 fibroblast growth factor receptor binding

Biological Process: cell-cell signaling; fibroblast growth factor receptor signaling pathway; MAPKKK cascade; nervous system development; phosphoinositide-mediated signaling; regulation of phosphoinositide 3-kinase cascade; signal transduction

Disease: Hypogonadotropic Hypogonadism 20 With Or Without Anosmia

NCBI Summary:This gene encodes a member of the fibroblast growth factor (FGF) family. Member of the FGF family possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is expressed during embryogenesis and in the adult cerebellum and cortex and may be essential for vascular growth and normal brain development. Mutations in this gene are the cause of hypogonadotropic hypogonadism 20 with or without anosmia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
UniProt Code:O60258
NCBI GenInfo Identifier:6015147
NCBI Gene ID:8822
NCBI Accession:O60258.1
UniProt Secondary Accession:O60258,Q2M2W1, B7ZLG4,
UniProt Related Accession:O60258
Molecular Weight:23,669 Da
NCBI Full Name:Fibroblast growth factor 17
NCBI Synonym Full Names:fibroblast growth factor 17
NCBI Official Symbol:FGF17��
NCBI Official Synonym Symbols:HH20; FGF-13; FGF-17��
NCBI Protein Information:fibroblast growth factor 17
UniProt Protein Name:Fibroblast growth factor 17
Protein Family:Fibroblast growth factor
UniProt Gene Name:FGF17��
UniProt Entry Name:FGF17_HUMAN
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