Growth Factors & Cytokines Recombinant Proteins
Human FGF12 Recombinant Protein (RPPB0224)
- SKU:
- RPPB0224
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P61328
- Research Area:
- Growth Factors & Cytokines
Description
| Product Name: | Human FGF12 Recombinant Protein |
| Product Code: | RPPB0224 |
| Size: | 10µg |
| Species: | Human |
| Target: | FGF12 |
| Synonyms: | FGF-12, FGF12, FGF12B, FHF1, Fibroblast growth factor 12, Fibroblast growth factor homologous factor 1, FHF-1, Myocyte-activating factor. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH7.4 and 1mM DTT. |
| Solubility: | It is recommended to reconstitute the lyophilized Fibroblast Growth Factor 12 in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized FGF12 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Fibroblast Growth Factor 12 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | MESKEPQLKG IVTRLFSQQG YFLQMHPDGT IDGTKDENSD YTLFNLIPVG LRVVAIQGVK ASLYVAMNGE GYLYSSDVFT PECKFKESVF ENYYVIYSST LYRQQESGRA WFLGLNKEGQ IMKGNRVKKT KPSSHFVPKP IEVCMYREQS LHEIGEKQGR SRKSSGTPTM NGGKVVNQDS T |
| Biological Activity: | Determined by FGF12 binding ability in a functional ELISA. Immobilized FGFR4/Fc Chimera at 5 �g/mL (100 �L/well) can bind FGF12 with a linear range of 1.6100 ng/mL. |
FGF12 is part of the Fibroblast Growth Factor (FGF) family which has a vast mitogenic and cell survival functions, and play a role in a range of biological activities, among them are embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-12 doesn�t obtain the N-terminal signal sequence present in the majority of the FGF family members, but it contains clusters of basic residues that act as a nuclear localization signal. When transfected into mammalian cells, FGF12 accumulated in the nucleus, but was not secreted. FGF12 is involved in nervous system development and function. FGF12 binds to IB2 (islet brain-2), a cellular kinase scaffold, and voltage gated sodium channels and is also involved in intracellular signalling and ion exchange.
Fibroblast Growth Factor 12 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 181 amino acids and having a molecular mass of 20.5kDa. The FGF12 is purified by proprietary chromatographic techniques.�
| UniProt Protein Function: | FGF12: Probably involved in nervous system development and function. Belongs to the heparin-binding growth factors family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell development/differentiation; Cytokine Chromosomal Location of Human Ortholog: 3q28 Cellular Component: extracellular space; intracellular; nucleus Molecular Function:fibroblast growth factor receptor binding; growth factor activity; heparin binding; protein binding; sodium channel regulator activity Biological Process: adult locomotory behavior; cell-cell signaling; fibroblast growth factor receptor signaling pathway; heart development; JNK cascade; nervous system development; neuromuscular process; signal transduction; synaptic transmission |
| NCBI Summary: | The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P61328 |
| NCBI GenInfo Identifier: | 47117683 |
| NCBI Gene ID: | 2257 |
| NCBI Accession: | P61328.1 |
| UniProt Secondary Accession: | P61328,O35339, P70376, Q8TBG5, Q92912, Q93001, B2R6B7 B2R976, |
| UniProt Related Accession: | P61328 |
| Molecular Weight: | 20,424 Da |
| NCBI Full Name: | Fibroblast growth factor 12 |
| NCBI Synonym Full Names: | fibroblast growth factor 12 |
| NCBI Official Symbol: | FGF12�� |
| NCBI Official Synonym Symbols: | FHF1; FGF12B�� |
| NCBI Protein Information: | fibroblast growth factor 12 |
| UniProt Protein Name: | Fibroblast growth factor 12 |
| UniProt Synonym Protein Names: | Fibroblast growth factor homologous factor 1; FHF-1; Myocyte-activating factor |
| Protein Family: | Fibroblast growth factor |
| UniProt Gene Name: | FGF12�� |
| UniProt Entry Name: | FGF12_HUMAN |
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