Human FETUB Recombinant Protein (RPPB3535)

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SKU:
RPPB3535
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q9UGM5

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human FETUB Recombinant Protein
Product Code:RPPB3535
Size:10µg
Species:Human
Target:FETUB
Synonyms:Fetuin-B, 16G2, Fetuin-like protein IRL685, Gugu, FETUB, IRL685.
Source:HEK293 Cells
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:FETUB filtered (0.4�m) and lyophilized from 0.5mg/ml in 0.05M phosphate buffer and 0.075M NaCl, pH 7.4.
Solubility:It is recommended to add deionized water to a working concentration of 0.5mg/ml and let the lyophilized pellet dissolve completely. FETUB is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:HSHVCGAMSP PQLALNPSAL LSRGCNDSDV LAVAGFALRD INKDRKDGYV LRLNRVNDAQ EYRRGGLGSL FYLTLDVLET DCHVLRKKAW QDCGMRIFFE SVYGQCKAIF YMNNPSRVLY LAAYNCTLRP VSKKKIYMTC PDCPSSIPTD SSNHQVLEAA TESLAKYNNE NTSKQYSLFK VTRASSQWVV GPSYFVEYLI KESPCTKSQA SSCSLQSSDS VPVGLCKGSL TRTHWEKFVS VTCDFFESQA PATGSENSAV NQKPTNLPKV EESQQKNTPP TDSPSKAGPR GSVQYLPDLD DKNSQEKGPQ EAFPVHLDLT TNPQGETLDI SFLFLEPMEE KLVVLPFPKE KARTAECPGP AQNASPLVLP PHHHHHH

Fetuin-B (FETUB) belongs to the fetuin family, part of the cystatin superfamily proteins and comprised of 2 cystatin domains. Fetuin-B is found in a secreted form in the serum, it is expressed in the liver, tongue and placenta. FETUB regulates osteogenesis by inhibition effect on mineralization. Fetuins are implicated in a number of various functions, including osteogenesis and bone resorption, regulation of the hepatocyte growth factor receptors, and response to systemic inflammation. FETUB also has a role in oocyte maturation. Fetuin-B is essential in preventing premature zona pellucida hardening before fertilization, probably by inhibiting the protease activity of ASTL, which is a protease that mediates the cleavage of ZP2 and triggers zona pellucida hardening.

Fetuin-B Human Recombinant produced in HEK cells is a single, glycosylated, polypeptide chain containing a total of 377 amino acids, having a molecular mass of 41.8kDa (calculated) though it migrates at approximately 55kDa on SDS PAGE, the Fetuin-B is also composed of a 4 a.a N-terminal linker and fused to a 6 a.a His tag at C-Terminus.The Human FETUB is purified by proprietary chromatographic techniques.

UniProt Protein Function:FETUB: is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q27

Cellular Component: extracellular space

Molecular Function:metalloendopeptidase inhibitor activity; cysteine protease inhibitor activity

Biological Process: binding of sperm to zona pellucida; single fertilization

NCBI Summary:The protein encoded by this gene is a member of the fetuin family, part of the cystatin superfamily of cysteine protease inhibitors. Fetuins have been implicated in several diverse functions, including osteogenesis and bone resorption, regulation of the insulin and hepatocyte growth factor receptors, and response to systemic inflammation. This protein may be secreted by cells. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UGM5
NCBI GenInfo Identifier:109940079
NCBI Gene ID:26998
NCBI Accession:Q9UGM5.2
UniProt Secondary Accession:Q9UGM5,Q1RMZ0, Q5J876, Q6DK58, Q6GRB6, Q9Y6Z0, B2RCW6 E9PG06,
UniProt Related Accession:Q9UGM5
Molecular Weight:37,823 Da
NCBI Full Name:Fetuin-B
NCBI Synonym Full Names:fetuin B
NCBI Official Symbol:FETUB��
NCBI Official Synonym Symbols:16G2; Gugu; IRL685��
NCBI Protein Information:fetuin-B; fetuin-like protein IRL685
UniProt Protein Name:Fetuin-B
UniProt Synonym Protein Names:16G2; Fetuin-like protein IRL685; Gugu
Protein Family:Fetuin
UniProt Gene Name:FETUB��
UniProt Entry Name:FETUB_HUMAN
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Developmental Biology Recombinant Proteins

system_update_altDatasheetHuman Fetuin-B/FETUB Recombinant Protein Fetuin-B is a member of the Fetuin family that is part of the Cystatin superfamily of Cysteine Protease inhibitors. It is report