Human Ferritin Recombinant Protein (RPPB3534)
- SKU:
- RPPB3534
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P02792
Description
| Product Name: | Human Ferritin Recombinant Protein |
| Product Code: | RPPB3534 |
| Size: | 25µg |
| Species: | Human |
| Target: | Ferritin |
| Synonyms: | Ferritin, FTL, MGC71996, Ferritin light chain. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered solution. |
| Formulation: | The protein solution (1mg/ml) contains 20mM Tris-HCl pH-7.5. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MSSQIRQNYS TDVEAAVNSL VNLYLQASYT YLSLGFYFDR DDVALEGVSH FFRELAEEKR EGYERLLKMQ NQRGGRALFQ DIKKPAEDEW GKTPDAMKAA MALEKKLNQA LLDLHALGSA RTDPHLCDFL ETHFLDEEVK LIKKMGDHLT NLHRLGGPEA GLGEYLFERL TLKHD |
Ferritin is a fairly large, iron-storage heteropolymeric protein composed of 2 subunit types, light Ferritin & heavy Ferritin polypeptides, which is expressed in most kinds of cells and co-assemble in different proportion in a tissue-specific manner. Ferritin is composed of 24 self-assembled polypeptide subunits of the heavy and light ferritin chains and is characterized by the capacity to remove Fe from solution in the presence of oxygen. Ferritin light polypeptide protein is the main intracellular iron storage protein in prokaryotes and eukaryotes. Variation in ferritin subunit composition influence the rates of iron uptake and release in various tissues. A key function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyper ferrit anemia-cataract syndrome. Ferritin stores iron in a soluble, nontoxic, readily accessible form. Ferritin is needed for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after it has been oxidized.
Ferritin Human Recombinant Light Chain produced in E.Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids and having a molecular mass of 20 kDa.
| UniProt Protein Function: | FTL: Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Defects in FTL are the cause of hereditary hyperferritinemia-cataract syndrome (HHCS). It is an autosomal dominant disease characterized by early-onset bilateral cataract. Affected patients have elevated level of circulating ferritin. HHCS is caused by mutations in the iron responsive element (IRE) of the FTL gene. Defects in FTL are the cause of neurodegeneration with brain iron accumulation type 3 (NBIA3); also known as adult-onset basal ganglia disease. It is a movement disorder with heterogeneous presentations starting in the fourth to sixth decade. It is characterized by a variety of neurological signs including parkinsonism, ataxia, corticospinal signs, mild nonprogressive cognitive deficit and episodic psychosis. It is linked with decreased serum ferritin levels. Belongs to the ferritin family. |
| UniProt Protein Details: | Protein type:Oxidoreductase Chromosomal Location of Human Ortholog: 19q13.33 Cellular Component: ferritin complex; membrane; cytosol Molecular Function:identical protein binding; protein binding; ferric iron binding; iron ion binding Biological Process: receptor-mediated endocytosis; iron ion homeostasis; cellular iron ion homeostasis; post-Golgi vesicle-mediated transport; iron ion transport; transmembrane transport Disease: Hyperferritinemia With Or Without Cataract; L-ferritin Deficiency; Neurodegeneration With Brain Iron Accumulation 3 |
| NCBI Summary: | This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P02792 |
| NCBI GenInfo Identifier: | 120523 |
| NCBI Gene ID: | 2512 |
| NCBI Accession: | P02792.2 |
| UniProt Secondary Accession: | P02792,Q6IBT7, Q7Z2W1, Q86WI9, Q8WU07, Q96AU9, Q96CU0 Q9BTZ8, B2R4B9, |
| UniProt Related Accession: | P02792 |
| Molecular Weight: | 440 kDa |
| NCBI Full Name: | Ferritin light chain |
| NCBI Synonym Full Names: | ferritin, light polypeptide |
| NCBI Official Symbol: | FTL�� |
| NCBI Official Synonym Symbols: | LFTD; NBIA3�� |
| NCBI Protein Information: | ferritin light chain; ferritin L-chain; ferritin L subunit; ferritin light polypeptide-like 3 |
| UniProt Protein Name: | Ferritin light chain |
| Protein Family: | Ferritin |
| UniProt Gene Name: | FTL�� |
| UniProt Entry Name: | FRIL_HUMAN |
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