Human FDX1 Recombinant Protein (RPPB3532)
- SKU:
- RPPB3532
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P10109
Description
| Product Name: | Human FDX1 Recombinant Protein |
| Product Code: | RPPB3532 |
| Size: | 25µg |
| Species: | Human |
| Target: | FDX1 |
| Synonyms: | Adrenodoxin mitochondrial, Adrenal ferredoxin, Ferredoxin-1, Hepatoredoxin, FDX1, ADX. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | The FDX1 solution contains 20mM Tris-HCl buffer (pH8.0) and 10% Glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MASMTGGQQM GRGSMSSSED KITVHFINRD GETLTTKGKV GDSLLDVVVE NNLDIDGFGA CEGTLACSTC HLIFEDHIYE KLDAITDEEN DMLDLAYGLT DRSRLGCQIC LTKSMDNMTV RVPETVADAR QSIDVGKTS |
Ferredoxin-1 is a small iron-sulfur protein who transfers electrons from NADPH through ferredoxin reductase to a terminal cytochrome P450. This specific oxidation/reduction system is located in steroidogenic tissues, and is involved with the synthesis of bile acid and vitamin D. FDX1 takes part in the synthesis of thyroid hormones and transfers electrons from adrenodoxin reductase to the cholesterol side chain cleavage cytochrome P450. FDX1 supports reactions catalyzed by human microsomal P450s- full length CYP17, truncated CYP17, and truncated CYP21. In addition to the FDX1 at the 11q22chromosomal locus, there are pseudogenes located on chromosomes 20 and 21.
FDX1 Human Recombinant fused with a 15 amino acid T7 tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 139 amino acids (61-184 a.a.) and having a molecular mass of 15.0kDa.The FDX1 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | adrenodoxin: Participates in the synthesis of thyroid hormones. Essential for the synthesis of various steroid hormones, participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to cytochrome P450 cholesterol side-chain cleavage enzyme. Belongs to the adrenodoxin/putidaredoxin family. |
| UniProt Protein Details: | Protein type:Mitochondrial Chromosomal Location of Human Ortholog: 11q22 Cellular Component: mitochondrion; mitochondrial matrix Molecular Function:2 iron, 2 sulfur cluster binding; electron carrier activity; iron ion binding Biological Process: steroid metabolic process; cholesterol metabolic process; xenobiotic metabolic process; C21-steroid hormone biosynthetic process; hormone biosynthetic process; sterol metabolic process |
| NCBI Summary: | This gene encodes a small iron-sulfur protein that transfers electrons from NADPH through ferredoxin reductase to mitochondrial cytochrome P450, involved in steroid, vitamin D, and bile acid metabolism. Pseudogenes of this functional gene are found on chromosomes 20 and 21. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P10109 |
| NCBI GenInfo Identifier: | 4758352 |
| NCBI Gene ID: | 2230 |
| NCBI Accession: | NP_004100.1 |
| UniProt Secondary Accession: | P10109,Q53YD6, B0YJ14, |
| UniProt Related Accession: | P10109 |
| Molecular Weight: | 19,393 Da |
| NCBI Full Name: | adrenodoxin, mitochondrial |
| NCBI Synonym Full Names: | ferredoxin 1 |
| NCBI Official Symbol: | FDX1�� |
| NCBI Official Synonym Symbols: | ADX; FDX; LOH11CR1D�� |
| NCBI Protein Information: | adrenodoxin, mitochondrial; ferredoxin-1; hepatoredoxin; adrenal ferredoxin; mitochondrial adrenodoxin |
| UniProt Protein Name: | Adrenodoxin, mitochondrial |
| UniProt Synonym Protein Names: | Adrenal ferredoxin; Ferredoxin-1; Hepatoredoxin |
| Protein Family: | Adrenodoxin |
| UniProt Gene Name: | FDX1�� |
| UniProt Entry Name: | ADX_HUMAN |
Related Products
Human RNAS2 Recombinant Protein
Human CSF2 Recombinant Protein (RPES5328)
Human CCL22 Recombinant Protein (RPES5343)
