Enzymes Recombinant Proteins

Human FDFT1 Recombinant Protein (RPPB1636)

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SKU:
RPPB1636
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P37268
Research Area:
Enzymes

Description

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Product Name:Human FDFT1 Recombinant Protein
Product Code:RPPB1636
Size:10µg
Species:Human
Target:FDFT1
Synonyms:Farnesyl-Diphosphate Farnesyltransferase 1, SqualeneSynthase, SQS, SS, FPP:FPP Farnesyltransferase, EC 2.5.1.21, DGPT, ERG9, Presqualene-Di-DiphosphateSynthase, Squalene Synthetase, Farnesyl-Diphosphate, Farnesyltransferase, FDFT1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FDFT1 protein solution (0.25 mg/ml) containing 20mMTris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMEFVKCL GHPEEFYNLV RFRIGGKRKV MPKMDQDSLS SSLKTCYKYLNQTSRSFAAV IQALDGEMRN AVCIFYLVLR ALDTLEDDMT ISVEKKVPLL HNFHSFLYQP DWRFMESKEKDRQVLEDFPT ISLEFRNLAE KYQTVIADIC RRMGIGMAEFLDKHVTSEQE WDKYCHYVAGLVGIGLSRLF SASEFEDPLV GEDTERANSM GLFLQKTNII RDYLEDQQGG REFWPQEVWS RYVKKLGDFA KPENIDLAVQCLNELITNAL HHIPDVITYL SRLRNQ

Farnesyl-Diphosphate Farnesyltransferase 1, also known as FDFT1 is amembrane-associated enzyme sited at a branch point in the mevalonate pathway. FDFT1belongs to the phytoene/squalene synthase family. FDFT1 is the 1st specificenzyme in cholesterol biosynthesis, which catalyzes the dimerization of 2molecules of farnesyl diphosphate in a two-step reaction to form squalene.

FDFT1 Human Recombinant produced in E.Coli is a single,non-glycosylated polypeptide chain containing 306 amino acids (1-283 a.a) andhaving a molecular mass of 35.4 kDa.�FDFT1 is fused to a 23 amino acid His-tag at N-terminus& purified by proprietary chromatographic techniques.

UniProt Protein Function:FDFT1: a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Oxidoreductase; EC 2.5.1.21; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Transferase; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p23.1-p22

Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane

Molecular Function:farnesyl-diphosphate farnesyltransferase activity

Biological Process: cholesterol biosynthetic process; steroid biosynthetic process

NCBI Summary:This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
UniProt Code:P37268
NCBI GenInfo Identifier:585126
NCBI Gene ID:2222
NCBI Accession:P37268.1
UniProt Secondary Accession:P37268,Q96GT0, B3KQ95, B4DJE5, B4DT56, B7Z1J3,
UniProt Related Accession:P37268
Molecular Weight:43,060 Da
NCBI Full Name:Squalene synthase
NCBI Synonym Full Names:farnesyl-diphosphate farnesyltransferase 1
NCBI Official Symbol:FDFT1��
NCBI Official Synonym Symbols:SS; SQS; DGPT; ERG9��
NCBI Protein Information:squalene synthase
UniProt Protein Name:Squalene synthase
UniProt Synonym Protein Names:FPP:FPP farnesyltransferase; Farnesyl-diphosphate farnesyltransferase
UniProt Gene Name:FDFT1��
UniProt Entry Name:FDFT_HUMAN
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