Human FDCSP Recombinant Protein (RPPB3531)
- SKU:
- RPPB3531
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q8NFU4
Description
| Product Name: | Human FDCSP Recombinant Protein |
| Product Code: | RPPB3531 |
| Size: | 20µg |
| Species: | Human |
| Target: | FDCSP |
| Synonyms: | Follicular dendritic cell secreted peptide, FDC secreted protein, FDC-SP, FDCSP, C4orf7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | FDCSP protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 7.5), 0.15M NaCl, 50% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSFPVSQDQ EREKRSISDS DELASGFFVF PYPYPFRPLP PIPFPRFPWF RRNFPIPIPE SAPTTPLPSE K |
Follicular Dendritic Cell Secreted Protein (FDCSP) is a small secreted protein which is found in follicular dendritic cells. The FDCSP protein specifically binds to activated B cells, and serves as a regulator of antibody responses. In addition, FDCSP is assumed to contribute to tumor metastases by promoting cancer cell migration and invasion. FDCSP binds to the surface of B-lymphoma cells, but not T-lymphoma cells, which is consistent with a function as a secreted mediator acting upon B-cells. FDCSP is abundantly expressed in the tonsil, lymph node, and tracheam, having a strong expression in the prostate and a lower expression in the thyroid, stomach and colon.
FDCSP Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 91 amino acids (18-85 a.a) and having a molecular mass of 10.4kDa.FDCSP is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FDCSP: Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.Protein type: Secreted, signal peptide; SecretedChromosomal Location of Human Ortholog: 4q13|4q13Cellular Component: extracellular region |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a small secreted protein that is expressed in follicular dendritic cells. This protein specifically binds to activated B cells, and functions as a regulator of antibody responses. It is also thought to contribute to tumor metastases by promoting cancer cell migration and invasion. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q8NFU4 |
| NCBI GenInfo Identifier: | 23308591 |
| NCBI Gene ID: | 260436 |
| NCBI Accession: | NP_694542 |
| UniProt Secondary Accession: | Q8NFU4 |
| UniProt Related Accession: | Q8NFU4 |
| Molecular Weight: | 9,700 Da |
| NCBI Full Name: | follicular dendritic cell secreted peptide |
| NCBI Synonym Full Names: | follicular dendritic cell secreted protein |
| NCBI Official Symbol: | FDCSP�� |
| NCBI Official Synonym Symbols: | C4orf7; FDC-SP�� |
| NCBI Protein Information: | follicular dendritic cell secreted peptide; FDC secreted protein |
| UniProt Protein Name: | Follicular dendritic cell secreted peptide |
| UniProt Synonym Protein Names: | |
| Protein Family: | Follicular dendritic cell secreted peptide |
| UniProt Gene Name: | FDCSP�� |
| UniProt Entry Name: | FDSCP_HUMAN |
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