Human FCMR Recombinant Protein (RPPB3530)

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RPPB3530

Description

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Product Name:Human FCMR Recombinant Protein
Product Code:RPPB3530
Size:10µg
Species:Human
Target:FCMR
Synonyms:Fas apoptotic inhibitory molecule 3, IgM Fc fragment receptor, Regulator of Fas-induced apoptosis Toso, FAIM3, TOSO.
Source:Escherichia Coli
Physical Appearance:Filtered White lyophilized (freeze-dried) powder.
Formulation:FCMR filtered (0.4 �m) and lyophilized from 0.5mg/ml in 50mM acetate buffer, pH 4.
Solubility:It is recommended to add 0.1M acetate buffer, pH 4 to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. In higher concentrations the solubility of this antigen is limited.
Stability:Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MKHHHHHHAS RILPEVKVEG ELGGSVTIKC PLPEMHVRIY LCREMAGSGT CGTVVSTTNF IKAEYKGRVT LKQYPRKNLF LVEVTQLTES DSGVYACGAG MNTDRGKTQK VTLNVHSEYE PSWEEQPMPE TPKWFHLPYL FQMPAYASSS KFVTRVTTPA QRGKVPPVHH SSPTTQITHR PRVSRASSVA GDKPRTFLPS TTASKISALE GLLKPQTPSY NHHTRLHRQR ALDYGSQSGR EGQ

Fas apoptotic inhibitory molecule 3 or FCMR takes part in processes occurring within the immune system. The FCMR is protecting cells from apoptosis that is induced by FADD, FAS and TNF alpha proteins, without over expressing inhibitors of apoptosis such as BCLXL or BCL2.� FCMR activates an inhibitory pathway that inhibits CASP8 activation, instead of blocking apoptotic signals downstream.

FCMR Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain (a.a 18-250) containing 243 amino acids including a 10 a.a N-terminal His tag. The total molecular mass is 27.2kDa (calculated).

UniProt Protein Function:FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: extracellular region; integral to membrane

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis

NCBI Summary:Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]
UniProt Code:O60667
NCBI GenInfo Identifier:74754378
NCBI Gene ID:9214
NCBI Accession:O60667.1
UniProt Related Accession:O60667
Molecular Weight:
NCBI Full Name:Fas apoptotic inhibitory molecule 3
NCBI Synonym Full Names:Fc fragment of IgM receptor
NCBI Official Symbol:FCMR��
NCBI Official Synonym Symbols:TOSO; FAIM3��
NCBI Protein Information:fas apoptotic inhibitory molecule 3
UniProt Protein Name:Fas apoptotic inhibitory molecule 3
UniProt Synonym Protein Names:Regulator of Fas-induced apoptosis Toso
Protein Family:Fas apoptotic inhibitory molecule
UniProt Gene Name:FAIM3��
UniProt Entry Name:FAIM3_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
O60667
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