CD Antigens Recombinant Proteins

Human FCGR2B Recombinant Protein (RPPB3525)

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SKU:
RPPB3525
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P31994
Research Area:
CD Antigens

Description

system_update_altDatasheetsystem_update_altMSDS
Product Name:Human FCGR2B Recombinant Protein
Product Code:RPPB3525
Size:10µg
Species:Human
Target:FCGR2B
Synonyms:CD32, CD32B, FCG2, FCGR2, IGFR2, Low affinity immunoglobulin gamma Fc region receptor II-b, CDw32, Fc-gamma-RIIb, FcRII-b.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered clear solution.
Formulation:FCGR2B protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 30% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 95.0% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMAPPKA VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAP

FCGR2B is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. FCGR2B participates in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. FCGR2B Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Variants in FCGR2B may increase susceptibilty to systemic lupus erythematosus (SLE).

FCGR2B Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 197 amino acids (46-217a.a.) and having a molecular mass of 22.0kDa. FCGR2Bis fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

NCBI Summary:The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
UniProt Code:P31994
NCBI GenInfo Identifier:
NCBI Gene ID:2213
NCBI Accession:
UniProt Related Accession:P31994
Molecular Weight:
NCBI Full Name:
NCBI Synonym Full Names:Fc fragment of IgG receptor IIb
NCBI Official Symbol:FCGR2B��
NCBI Official Synonym Symbols:CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcRII-c��
NCBI Protein Information:low affinity immunoglobulin gamma Fc region receptor II-b
UniProt Protein Name:
Protein Family:CD320 antigen
UniProt Gene Name:
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