CD Antigens Recombinant Proteins

Human FCGR2A Recombinant Protein (RPPB3524)

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RPPB3524

Description

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Product Name:Human FCGR2A Recombinant Protein
Product Code:RPPB3524
Size:10µg
Species:Human
Target:FCGR2A
Synonyms:CD32, CD32A, CDw32, FcGR, IGFR2, MGC23887, MGC30032, Low affinity immunoglobulin gamma Fc region receptor II-a, IgG Fc receptor II-a, Fc-gamma-RIIa, FcRII-a, FCG2, FCGR2A1.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:FCGR2A protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 50% glycerol and 1mM DTT.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 90% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSHMQAAPP KAVLKLEPPW INVLQEDSVT LTCQGARSPE SDSIQWFHNG NLIPTHTQPS YRFKANNNDS GEYTCQTGQT SLSDPVHLTV LSEWLVLQTP HLEFQEGETI MLRCHSWKDK PLVKVTFFQN GKSQKFSRLD PTFSIPQANH SHSGDYHCTG NIGYTLFSSK PVTITVQVPS MGSSSPMG

CD32a, also known as FCGR2A, belongs to a family of immunoglobulin Fc receptor genes located on the surface of various immune response cells. FCGR2A which is a cell surface receptor found on phagocytic cells like macrophages and neutrophils, takes part in the process of phagocytosis and clearing of immune complexes. FCGR2A initiates cellular responses against pathogens and soluble antigens by binding to IgG. FCGR2A, which is a low affinity receptor, binds to the Fc region of immunoglobulins gamma.

FCGR2A Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 208 amino acids (34-216 a.a) and having a molecular mass of 23.0kDa. FCGR2A is fused to a 25 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:NT5E: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Homodimer; disulfide-linked. Belongs to the 5'-nucleotidase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.1.3.5; Membrane protein, integral; Nucleotide Metabolism - pyrimidine; Nucleotide Metabolism - purine; Phosphatase (non-protein); Membrane protein, GPI anchor; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide

Chromosomal Location of Human Ortholog: 6q14-q21

Cellular Component: cell surface; membrane; cytoplasm; plasma membrane

Molecular Function:5'-nucleotidase activity; metal ion binding; nucleotide binding

Biological Process: pyrimidine nucleoside catabolic process; dephosphorylation; pyrimidine base metabolic process; nucleobase, nucleoside and nucleotide metabolic process; adenosine biosynthetic process; negative regulation of inflammatory response; purine nucleotide catabolic process; DNA metabolic process; purine base metabolic process; AMP catabolic process

Disease: Calcification Of Joints And Arteries

NCBI Summary:The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
UniProt Code:P21589
NCBI GenInfo Identifier:112825
NCBI Gene ID:4907
NCBI Accession:P21589.1
UniProt Related Accession:P21589
Molecular Weight:
NCBI Full Name:5'-nucleotidase
NCBI Synonym Full Names:5'-nucleotidase ecto
NCBI Official Symbol:NT5E��
NCBI Official Synonym Symbols:NT; eN; NT5; NTE; eNT; CD73; E5NT; CALJA��
NCBI Protein Information:5'-nucleotidase
UniProt Protein Name:5'-nucleotidase
UniProt Synonym Protein Names:Ecto-5'-nucleotidase; CD_antigen: CD73
UniProt Gene Name:NT5E��
UniProt Entry Name:5NTD_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P21589
Research Area:
CD Antigens
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