CD64 (Fc?RI), one of the Fc receptors for IgG, is a membrane glycoprotein that mediates endocytosis, phagocytosis, antibody-dependent cellular cytotoxicity, cytokine release, and superoxide production. CD64 is also structurally distinct, containing an extracellular Ig-interactive region of three Ig-like domains in contrast to the two domains of the low affinity receptors Fc?RII and Fc?RIII. It is normally expressed on the surfaces of monocytes and macrophages.
Product Name:
Human FCGR1A/CD64 Recombinant Protein (RPES2238)
Product Code:
RPES2238
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Ig gamma-4 chain C region,IgG4 Fc
Accession:
P12314
Sequence:
Gln16-Pro288
Fusion tag:
C-His
Activity:
Immobilized Human SIgG1-Fc(Cat: PKSH032558) at 2µg/ml(100 ?l/well) can bind Human CD64-His(Cat: PKSM041277). The ED50 of Human CD64-His is 0.05ug/ml .
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human FCGR1A is produced by our Mammalian expression system and the target gene encoding Gln16-Pro288 is expressed with a 6His tag at the C-terminus.
Purity:
> 95% as determined by reducing SDS-PAGE.
Mol Mass:
31.7 kDa
AP Mol Mass:
50-70 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
system_update_altDatasheetRat FCGR1A/CD64 Recombinant Protein High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a mem
system_update_altDatasheetMouse CD64/FCGR1 Recombinant Protein High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a me
system_update_altDatasheetMouse CD64/FCGR1 Recombinant Protein High affinity immunoglobulin gamma Fc receptor I, also known as FCGR1 and CD64, is an integral membrane glycoprotein and a me
system_update_altDatasheetMouse CD64/FCGR1 Recombinant Protein CD64, also known as Fc-gamma receptor 1 (Fc?RI), is a type of integral membrane glycoprotein that binds monomeric IgG-type antibodie