Human FCER1A 201 a.a Recombinant Protein (RPPB3523)

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RPPB3523

Description

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Product Name:Human FCER1A 201 a.a Recombinant Protein
Product Code:RPPB3523
Size:50µg
Species:Human
Target:FCER1A 201 a.a
Synonyms:Fc Fragment Of IgE, High Affinity I, Receptor For; Alpha Polypeptide, FCE1A, IgE Fc Receptor Subunit Alpha, FcERI, Fc-Epsilon RI-Alpha, Fc Epsilon RI Alpha-Chain, Fc IgE Receptor, Alpha Polypeptide, High Affinity Immunoglobulin Epsilon Receptor Alpha-Subunit, High Affinity Immunoglobulin Epsilon Receptor Subunit Alpha, Immunoglobulin E Receptor, High-Affinity, Of Mast Cells, Alpha Polypeptide.
Source:Escherichia Coli
Physical Appearance:Sterile Filtered colorless solution.
Formulation:1x PBS, 50mM Arginine and 0.05% NaN3.
Stability:The Recombinant FCER1A protein although stable at 4°C for 1 week, should be stored below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Purity:Greater than 90.0% as determined by SDS-PAGE.
Amino Acid Sequence:HMAPAMESPTL LCVALLFFAP DGVLAVPQKP KVSLNPPWNR IFKGENVTLT �CNGNNFFEVS STKWFHNGSL SEETNSSLNI VNAKFEDSGE YKCQHQQVNE SEPVYLEVFS DWLLLQASAE VVMEGQPLFL RCHGWRNWDV YKVIYYKDGE �ALKYWYENHN ISITNATVED SGTYYCTGKV WQLDYESEPL NITVIKAPLEHHHHHH

Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide (FCER1A) binds to the Fc region of immunoglobulins epsilon. FCER1A is a high affinity receptor. In addition FCER1A is responsible for starting the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators such as histamine which is responsible for the manifestations of allergy. This receptor is contains of an alpha subunit, a beta subunit, and two gamma subunits. FCER1A stands for the alpha subunit. Among the diseases associated with FCER1A are mast-cell leukemia, and allergic asthma.

FCER1A Human Recombinant produced in E.Coli is a non-glycosylated polypeptide chain containing 201 amino acids.FCER1Ais fused to a 6 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:Binds to the Fc region of immunoglobulins epsilon. High affinity receptor. Responsible for initiating the allergic response. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators (such as histamine) responsible for the manifestations of allergy. The same receptor also induces the secretion of important lymphokines.
NCBI Summary:The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
UniProt Code:P12319
NCBI GenInfo Identifier:119865
NCBI Gene ID:2205
NCBI Accession:P12319.1
UniProt Related Accession:P12319
Molecular Weight:30kDa
NCBI Full Name:High affinity immunoglobulin epsilon receptor subunit alpha
NCBI Synonym Full Names:Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
NCBI Official Symbol:FCER1A��
NCBI Official Synonym Symbols:FCE1A; FcERI��
NCBI Protein Information:high affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; Fc epsilon RI alpha-chain; igE Fc receptor subunit alpha; Fc IgE receptor, alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
UniProt Protein Name:High affinity immunoglobulin epsilon receptor subunit alpha
UniProt Synonym Protein Names:Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha
Protein Family:High affinity immunoglobulin epsilon receptor
UniProt Gene Name:FCER1A��
UniProt Entry Name:FCERA_HUMAN
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Additional Information

Product Type:
Recombinant Protein
Species:
Human
Uniprot:
P12319
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