Human FCAR Recombinant Protein (RPPB3518)
- SKU:
- RPPB3518
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- P24071
Description
| Product Name: | Human FCAR Recombinant Protein |
| Product Code: | RPPB3518 |
| Size: | 5µg |
| Species: | Human |
| Target: | FCAR |
| Synonyms: | Fc Fragment Of IgA Receptor, Fc Fragment Of IgA, Receptor For, CD89, Immunoglobulin Alpha Fc Receptor, Fc Alpha Receptor, FCAR Variant 14, IgA Fc Receptor, CD89 Antigen,�CTB-61M7.2, FcalphaRI, Immunoglobulin alpha Fc receptor, IgA Fc receptor. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | FCAR protein solution (0.25mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 85.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | ADPQEGDFPM PFISAKSSPV IPLDGSVKIQ CQAIREAYLT QLMIIKNSTY REIGRRLKFW NETDPEFVID HMDANKAGRY QCQYRIGHYR FRYSDTLELV VTGLYGKPFL SADRGLVLMP GENISLTCSS AHIPFDRFSL AKEGELSLPQ HQSGEHPANF SLGPVDLNVS GIYRCYGWYN RSPYLWSFPS NALELVVTDS IHQDYTTQNH HHHHH |
Fc Fragment Of IgA Receptor, also known as FCAR, is part of the multichain immune recognition receptor family which is the most abundant immunoglobulin in mucosal areas however it is only the second most common antibody isotype in serum. FCAR participates in both pro-and anti-inflammatory responses depending on the state of IgA bound. FCAR is also a vital Fc receptor for neutrophil killing of tumor cells. Once FCAR expressing neutrophils interact with IgA-opsonized tumor cells, the neutrophils not only show antibody-dependent cell-mediated cytotoxicity, but also release the cytokines TNF-? and IL-1Beta which cause increased neutrophil migration to the site.
FCAR produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 215 amino acids (22-227a.a.) and having a molecular mass of 24.5kDa. (Molecular size on SDS-PAGE will appear at approximately 28-40kDa).FCAR is expressed with a 9 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. |
| NCBI Summary: | This gene is a member of the immunoglobulin gene superfamily and encodes a receptor for the Fc region of IgA. The receptor is a transmembrane glycoprotein present on the surface of myeloid lineage cells such as neutrophils, monocytes, macrophages, and eosinophils, where it mediates immunologic responses to pathogens. It interacts with IgA-opsonized targets and triggers several immunologic defense processes, including phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24071 |
| NCBI GenInfo Identifier: | 119860 |
| NCBI Gene ID: | 2204 |
| NCBI Accession: | P24071.1 |
| UniProt Related Accession: | P24071 |
| Molecular Weight: | |
| NCBI Full Name: | Immunoglobulin alpha Fc receptor |
| NCBI Synonym Full Names: | Fc fragment of IgA receptor |
| NCBI Official Symbol: | FCAR�� |
| NCBI Official Synonym Symbols: | CD89; FcalphaRI; CTB-61M7.2�� |
| NCBI Protein Information: | immunoglobulin alpha Fc receptor |
| UniProt Protein Name: | Immunoglobulin alpha Fc receptor |
| UniProt Synonym Protein Names: | CD_antigen: CD89 |
| UniProt Gene Name: | FCAR�� |
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