Human FAM84B Recombinant Protein (RPPB3515)

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SKU:
RPPB3515
Product Type:
Recombinant Protein
Species:
Human
Uniprot:
Q96KN1

Description

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Product Name:Human FAM84B Recombinant Protein
Product Code:RPPB3515
Size:20µg
Species:Human
Target:FAM84B
Synonyms:FAM84B, Family with Sequence Similarity 84 Member B, BCMP101, Breast Cancer Membrane-Associated Protein 101, Neurological/Sensory 2, Breast Cancer Membrane Protein 101, NSE2, Protein FAM84B, Protein NSE2.
Source:Escherichia Coli
Physical Appearance:Sterile filtered colorless solution.
Formulation:The FAM84B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 10% glycerol, 0.15M NaCl, 1mM DTT and 0.1mM PMSF.
Stability:Store at 4°C if entire vial will be used within 2-4 weeks.�Store, frozen at -20°C for longer periods of time.�For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.
Purity:Greater than 85% as determined by SDS-PAGE.
Amino Acid Sequence:MGSSHHHHHH SSGLVPRGSH MGSMGNQVEK LTHLSYKEVP TADPTGVDRD DGPRIGVSYI FSNDDEDVEP QPPPQGPDGG GLPDGGDGPP PPQPQPYDPR LHEVECSVFY RDECIYQKSF APGSAALSTY TPENLLNKCK PGDLVEFVSQ AQYPHWAVYV GNFQVVHLHR LEVINSFLTD ASQGRRGRVV NDLYRYKPLS SSAVVRNALA HVGAKERELS WRNSESFAAW CRYGKREFKI GGELRIGKQP YRLQIQLSAQ RSHTLEFQSL EDLIMEKRRN DQIGRAAVLQ ELATHLHPAE PEEGDSNVAR TTPPPGRPPA PSSEEEDGEA VAH

Family with Sequence Similarity 84, Member B (FAM84B) coprecipitated with a downstream effector of RAS, CRAF. Binding of FAM83B with CRAF interrupted CRAF/14-3-3 interactions and increased CRAF membrane localization, causing elevated MAPK and mammalian target of rapamycin (mTOR) signaling. FAM84B is an oncogene and possibly represents a new target for therapeutic intervention.

FAM84B Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 333 amino acids (1-310) and having a molecular mass of 36.9kDa.FAM84B is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

UniProt Protein Function:FAM84B: Belongs to the FAM84 family.
UniProt Protein Details:

Protein type:Unknown function

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytoplasm; plasma membrane

Molecular Function:protein binding

UniProt Code:Q96KN1
NCBI GenInfo Identifier:74732219
NCBI Gene ID:157638
NCBI Accession:Q96KN1.1
UniProt Related Accession:Q96KN1
Molecular Weight:34,474 Da
NCBI Full Name:Protein FAM84B
NCBI Synonym Full Names:family with sequence similarity 84 member B
NCBI Official Symbol:FAM84B��
NCBI Official Synonym Symbols:NSE2; BCMP101��
NCBI Protein Information:protein FAM84B
UniProt Protein Name:Protein FAM84B
UniProt Synonym Protein Names:Breast cancer membrane protein 101; Protein NSE2
Protein Family:Protein
UniProt Gene Name:FAM84B��
UniProt Entry Name:FA84B_HUMAN
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