Human FAIM Recombinant Protein (RPPB3507)
- SKU:
- RPPB3507
- Product Type:
- Recombinant Protein
- Species:
- Human
- Uniprot:
- Q9NVQ4
Description
| Product Name: | Human FAIM Recombinant Protein |
| Product Code: | RPPB3507 |
| Size: | 20µg |
| Species: | Human |
| Target: | FAIM |
| Synonyms: | FAIM1, Fas Apoptotic Inhibitory Molecule, FAIM2, LFG, NMP35,Fas Apoptotic Inhibitory Molecule 1, FAIM. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | FAIM protein solution (0.5 mg /ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.4M UREA and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please avoid freeze thaw cycles. |
| Purity: | Greater than 85% as determined by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSMLLPFIR TLPLLCYNHL LVSPDSATLS PPYSLEKMTD LVAVWDVALS DGVHKIEFEH GTTSGKRVVY VDGKEEIRKE WMFKLVGKET FYVGAAKTKA TINIDAISGF AYEYTLEING KSLKKYMEDR SKTTNTWVLH MDGENFRIVL EKDAMDVWCN GKKLETAGEF VDDGTETHFS IGNHDCYIKA VSSGKRKEGI IHTLIVDNRE IPEIAS |
Fasapoptotic inhibitory molecule, also known as FAIM function as an inducibleeffector molecule which mediates Fas resistance produced by surface Ig engagementin B cells. In addition FAIM protects against death receptor-triggeredapoptosis and regulates B-cell signaling and differentiation. Among thediseases associated with FAIM are hemorrhagic thrombocythemia, and food allergy.
FAIM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 236 amino acids (1-213aa) and having a molecular mass of 26.4kDa.FAIM is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | FAIM: Plays a role as an inducible effector molecule that mediates Fas resistance produced by surface Ig engagement in B cells. Belongs to the FAIM1 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis Chromosomal Location of Human Ortholog: 3q22.3 Cellular Component: cytoplasm Biological Process: apoptosis; negative regulation of apoptosis |
| NCBI Summary: | The protein encoded by this gene protects against death receptor-triggered apoptosis and regulates B-cell signaling and differentiation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] |
| UniProt Code: | Q9NVQ4 |
| NCBI GenInfo Identifier: | 38503210 |
| NCBI Gene ID: | 55179 |
| NCBI Accession: | Q9NVQ4.1 |
| UniProt Related Accession: | Q9NVQ4 |
| Molecular Weight: | 20kDa |
| NCBI Full Name: | Fas apoptotic inhibitory molecule 1 |
| NCBI Synonym Full Names: | Fas apoptotic inhibitory molecule |
| NCBI Official Symbol: | FAIM�� |
| NCBI Official Synonym Symbols: | FAIM1�� |
| NCBI Protein Information: | fas apoptotic inhibitory molecule 1 |
| UniProt Protein Name: | Fas apoptotic inhibitory molecule 1 |
| Protein Family: | Fas apoptotic inhibitory molecule |
| UniProt Gene Name: | FAIM�� |
| UniProt Entry Name: | FAIM1_HUMAN |
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