Immunology Recombinant Proteins
Human Factor D Recombinant Protein (RPES4432)
- SKU:
- RPES4432
- Product Type:
- Recombinant Protein
- Species:
- Human
- Research Area:
- Immunology
Description
Human Factor D Recombinant Protein
Complement factor D; also known as adipsin; is a member of the chymotrypsin family of serine proteases; which plays an essential role in host defense as the rate-limiting enzyme in the alternative pathway of complement activation. Complement factor D activates a convertase (C3bBb) responsible for cleavage of the complement protein C3; which leads to the activation of terminal complement component C5-9 to form the membrane attack complex on microbial or cellular surfaces. It also functions in the regulation of systemic energy balance and physiologic and pathologic processes; including immunity and inflammation.
| Product Name: | Human Factor D Recombinant Protein (RPES4432) |
| Product Code: | RPES4432 |
| Size: | 10µg |
| Species: | Human |
| Expressed Host: | Human Cells |
| Synonyms: | Complement factor D, CFD, Adipsin, C3 convertase activator, Properdin factor D, DF, PFD,ADIPSIN,ADN,DF,FACTOR D |
| Accession: | P00746 |
| Sequence: | Ile26-Ala253 |
| Fusion tag: | C-10His |
| Endotoxin: | <1.0 EU per µg as determined by the LAL method. |
| Protein Construction: | Recombinant Human Complement factor D is produced by our Mammalian expression system and the target gene encoding Ile26-Ala253 is expressed with a 10His tag at the C-terminus. |
| Purity: | > 95 % as determined by reducing SDS-PAGE. |
| Mol Mass: | 25.8 kDa |
| AP Mol Mass: | 28 kDa |
| Formulation: | Lyophilized from a 0.2 µm filtered solution of 20mM Tris; 150mM NaCl; pH7.5. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
| Stability and Storage: | Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months. |
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